Tuberculosis and Respiratory Diseases
- Volume 52 Issue 3
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- Pages.260-264
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- 2002
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- 1738-3536(pISSN)
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- 2005-6184(eISSN)
A Case of Severe Bleomycin-Induced Pneumonitis at Non-Hodgkin's Lymphoma
비호즈킨 림프종 환자에서 저용량의 Bleomycin에 의해 발생한 급성 중증 폐독성 1예
- Han, Dong-Ha (Department of Internal Medicine, Ulsan University Hospital University of Ulsan College of Medicine) ;
- Min, Young-Joo (Department of Internal Medicine, Ulsan University Hospital University of Ulsan College of Medicine) ;
- Yoon, Je-Hyun (Department of Internal Medicine, Ulsan University Hospital University of Ulsan College of Medicine) ;
- Park, Jong-Ho (Department of Internal Medicine, Ulsan University Hospital University of Ulsan College of Medicine) ;
- Ahn, Jong-Joon (Department of Internal Medicine, Ulsan University Hospital University of Ulsan College of Medicine) ;
- Lee, Ki-Man (Department of Internal Medicine, Ulsan University Hospital University of Ulsan College of Medicine) ;
- Park, Jae-Hoo (Department of Internal Medicine, Ulsan University Hospital University of Ulsan College of Medicine)
- 한동하 (울산대학교 의과대학 울산대학교병원 내과학교실) ;
- 민영주 (울산대학교 의과대학 울산대학교병원 내과학교실) ;
- 윤제현 (울산대학교 의과대학 울산대학교병원 내과학교실) ;
- 박종호 (울산대학교 의과대학 울산대학교병원 내과학교실) ;
- 안종준 (울산대학교 의과대학 울산대학교병원 내과학교실) ;
- 이기만 (울산대학교 의과대학 울산대학교병원 내과학교실) ;
- 박재후 (울산대학교 의과대학 울산대학교병원 내과학교실)
- Published : 2002.03.30
Abstract
Bleomycin-induced pulmonary toxicity usually occurs in the elderly patients (greater than 70 years old), patients with a cumulative dose above 400 units, previous chest radiotherapy, oxygen therapy, and renal failure. However, there are some reports of severe pneumonitis that developed after administering low bleomycin doses(less than 100 units). In severe bleomycin-induced pneumonitis in non-Hodgkin's lymphoma patients, the response to corticosteroid is poor and the mortality rate is very high, approximately 83%. Therefore, clinicians should have a low threshold for investigating and treating bleomycin-induced pneumonitis. Here, we report a case of severe bleomycin-induced pneumonitis as a complication of a non-Hodgkin's lymphoma treatment.
저자들은 비호즈킨 림프종 환자에서 bleomycin, doxorubicin, prednisolone, cyclophosphamide의 복합 항암화학요법을 시행하던 중, bleomycin 축적 용량 90단위에서 중증의 폐독성이 빠르게 진행하는 급성호흡부전의 형태로 발생하여 기계호흡 등의 보존적 치료 후 폐 섬유화 소견을 남기고 회복하는 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.