Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
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Concomitant Chemoradiotherapy as Primary Therapy for Advanced Head and Neck Cancer

진행된 두경부암에서의 항암방사선 동시요법의 치료효과

  • Lee Joo-Yun (Department of Otolaryngology, College of Medicine Chungbuk National University) ;
  • Lee Dong-Wook (Department of Otolaryngology, College of Medicine Chungbuk National University) ;
  • Choi Young-Seok (Department of Otolaryngology, College of Medicine Chungbuk National University) ;
  • Jin Hong-Ryul (Department of Otolaryngology, College of Medicine Chungbuk National University) ;
  • Lee Hyun-Seok (Department of Otolaryngology, College of Medicine Chungbuk National University) ;
  • Yeon Je-Yeob (Department of Otolaryngology, College of Medicine Chungbuk National University) ;
  • Shin See-Ok (Department of Otolaryngology, College of Medicine Chungbuk National University)
  • 이주연 (충북대학교 의과대학 이비인후과학교실) ;
  • 이동욱 (충북대학교 의과대학 이비인후과학교실) ;
  • 최영석 (충북대학교 의과대학 이비인후과학교실) ;
  • 진홍률 (충북대학교 의과대학 이비인후과학교실) ;
  • 이현석 (충북대학교 의과대학 이비인후과학교실) ;
  • 연제엽 (충북대학교 의과대학 이비인후과학교실) ;
  • 신시옥 (충북대학교 의과대학 이비인후과학교실)
  • Published : 2002.11.01
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Abstract

Background: To achieve the efficacy and toxic effects of concomitant FP chemoradiotherapy regimen by means of response and survival in patients with advanced head and neck cancer. Patient and Method: Thirty-three previously untreated patients with newly diagnosed advanced head and neck cancer were retrospectively reviewed. Results: Thirty-one patients were evaluable for the tumor response. Total response rate was 93%(complete response 60%, partial response 33%). Disease free survival was 37 month and 3-year overall survival was 63%. Grade 3 or 4 stomatitis was observed in 83% and appeared as the dose limiting toxicity for this regimen. Conclusion: Concomitant chemoradiotherapy with cisplastin and 5-fluorouracil is effective as primary therapy for advanced head and neck cancer. The majority of patients experienced severe stomatitis. Identification of less toxic regiment and improved disease control emerge as important future research goals.

Keywords

References

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