IMMUNE NETWORK
- 제2권4호
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- Pages.202-207
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- 2002
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- 1598-2629(pISSN)
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- 2092-6685(eISSN)
Production of Plasma Leptin and Expression of Interferon-γ Inducible Protein-10 (IP-10), Monokine Induced by Interferon-γ (Mig) and Interleukin-8 (IL-8) mRNA in Kawasaki Disease
- Lee, Young-Hwan (Department of Pediatrics, College of Medicine, Yeungnam University) ;
- Kim, Won-Duk (Department of Pediatrics, College of Medicine, Dongguk University) ;
- Kim, Hee-Sun (Department of Microbiology, College of Medicine, Yeungnam University)
- 발행 : 2002.12.31
초록
Background: Kawasaki disease is an acute febrile illness with systemic vasculitis which primarily affects children, We examined the production of leptin in plasma and gene expressions of CXC chemokines in peripheral blood mononuclear cells from patients with Kawasaki disease. Methods: Consecutive 39 samples from 13 patients according to the different clinical stages (acute, subacute, convalescent) of Kawasaki disease were collected. The plasma leptin levels according to clinical stages of Kawasaki disease were examined by ELISA and the expression of IP-10, Mig and IL-8 mRNAs in 39 samples (13 samples of each stage) from 13 cases were examined by RT-PCR. Results: There were not significant changes of plasma leptin levels according to the clinical stages of Kawasaki disease. The mean values of plasma leptin concentrations during each of the stages (n=13, p>0.05, pg/ml) were