IMMUNE NETWORK
- Volume 2 Issue 3
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- Pages.166-174
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- 2002
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- 1598-2629(pISSN)
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- 2092-6685(eISSN)
Differentiation of Osteoblast Progenitor Cells from Human Umbilical Cord Blood
제대혈액에서 골조직 특이세포로의 분화
- Hong, Seung-Jin (Department of Microbiology and Immunology, College of Medicine, The Catholic University of Korea) ;
- Lee, Eun-A (Histostem Corporation) ;
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Chae, Gue-Tae
(Department of Pathology, College of Medicine, The Catholic University of Korea) ;
- Han, Hoon (Department of Microbiology and Immunology, College of Medicine, The Catholic University of Korea)
- Published : 2002.09.30
Abstract
Background: Human umbilical cord bloods, which could be taken during the delivery are utilized as a source of hematopoietic stem cells. Also in cord blood, there are several kinds of stem cells such as endothelial and mesenchymal stem cells. Methods: We isolated the mesenchymal stem cells from human umbilical cord bloods and confirmed the differentiation of these cells into osteoblast progenitor cells. The mesenchymal stem cells derived from umbilical cord blood have the ability to differentiate into specific tissue cells, which is one of characteristics of stem cells. These cells were originated from the multipolar shaped cells out of adherent cells of the umbilical cord blood mononuclear cell culture. Results: The mesenchymal stem cells expressed cell surface antigen CD13, CD90, CD102, CD105,