Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Crataegi Fructus on the Vascular Relaxation and Antioxidative Status

산사의 혈관이완 효능과 항산화 작용

  • Son Chang Woo (Department of Physiology, Dongguk University College of Oriental Medicine) ;
  • Chae Jong Koo (Department of Physiology, Dongguk University College of Oriental Medicine) ;
  • Kim Gil Whon (Department of Physiology, Dongguk University College of Oriental Medicine) ;
  • Shin Heung Mook (Department of Physiology, Dongguk University College of Oriental Medicine)
  • 손창우 (동국대학교 한의과대학 생리학교실) ;
  • 채종구 (동국대학교 한의과대학 생리학교실) ;
  • 김길훤 (동국대학교 한의과대학 생리학교실) ;
  • 신흥묵 (동국대학교 한의과대학 생리학교실)
  • Published : 2002.02.01
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Abstract

This study investigated the relaxation effects of Crataegi Fructus(CF, Crataegus pinnatifida Bunge) on the contraction evoked by phenylephrine in rabbit carotid artery, and also analyzes antioxidative status in vitro. CF revealed siginificant relaxation on phenylephrine-induced arterial contraction. It's relaxant effect statistically significant in both in the presence of endothelium and absence of endothelium, but statistically exerted more strong relaxation in the presence of endothelium. CF increased in vitro nitric oxide(NO) production in dose-dependent manner. Also, they reduced malondiaidehyde(MDA) concentrations, phosphatidyl choline-liposome(PCOOH) contents, linoleic acid-induced lipid peroxidation and exerted 1,1-diphenyl-2- picryl-hydrazyl(DPPH) radical scavenging effect, in vitro. These results indicate that Crataegi Fructus would be effective in relaxing arterial contraction and it's antioxidative effects may be involved in endothelium-dependent relaxation of artery via vascular protective properites.

Keywords

References

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