Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Ameliorating Effects of the Cognitive-Enhancing Korean Herbs on Neurotoxic-Induced Amnesia in Rats

새로운 제형의 치매치료제제의 효능연구

  • Kim Ji Hyun (Department of Oriental Medical Science. Graduate School of East-West Medical Science, Kyunghee University) ;
  • Jung Jin Yong (Department of Oriental Medical Science. Graduate School of East-West Medical Science, Kyunghee University) ;
  • Chae Yoon Byung (Department of Oriental Medical Science. Graduate School of East-West Medical Science, Kyunghee University) ;
  • Hahm Dae Hyun (Department of Oriental Medical Science. Graduate School of East-West Medical Science, Kyunghee University) ;
  • Park Yang Jin (Bak Nam Oriental Medical Clinic) ;
  • Lee Hye Jung (Department of Oriental Medical Science. Graduate School of East-West Medical Science, Kyunghee University) ;
  • Shim Insop (Department of Oriental Medical Science. Graduate School of East-West Medical Science, Kyunghee University)
  • 김지현 (경희대학교 동서의학대학원 침구경락학교실) ;
  • 정진용 (경희대학교 동서의학대학원 침구경락학교실) ;
  • 채윤병 (경희대학교 동서의학대학원 침구경락학교실) ;
  • 함대현 (경희대학교 동서의학대학원 침구경락학교실) ;
  • 박용진 (대전시 서구 둔산동 백남한의원) ;
  • 이혜정 (경희대학교 동서의학대학원 침구경락학교실) ;
  • 심인섭 (경희대학교 동서의학대학원 침구경락학교실)
  • Published : 2002.04.01
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Abstract

Ancient Korean physicians have used several oriental herbs to cure dementia and these effects were described in the Korean herbal books. Some cognitive-enhancing oriental herbs have been widely used as a herbal medicine against dementia. However, few of studies have proved their efficacy in treatment for dementia. In the present study, we investigated the effects of herbal compounds, which are mainly consisted of Uncaria sinensis, Corydalis yanhusuo and Acorus gramineus on learning and memory in Mortis water maze task and the central cholinergic system of the rats with neurotoxic medial septum lesion. In water maze test, the animals were trained to find a platform in a fixed position during 6 days and then received a 60-s probe trial in which the platform was removed from the pool on the 7th day. Ibotanic and 192 saporin lesion of the medial septum (MS) impaired the performance of maze test and degenerated choline acetyltransferase (ChAT) in the brain, which is a marker of the central cholinergic system. Daily administrations of herbal medicine (100mg/kg, p.o.) for 21 consecutive days produced significant reversals of the neurotoxic-induced deficit in learning and memory. These treatments also reduced the loss of cholinergic immunoreactive neurons in the brain induced by neurotoxin. These results demonstrated that herbal compounds ameliorated learning and memory deficits through effects on the central nervous system, partly through effect on the acetylcholine system. Our studies suggest an evidence of these herbs as treatment of Alzheimer's disease.

Keywords

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