Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Immunoregulatory Action of Comus officinalis Sieb.et Zucc

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  • Lee Won Bum (Department of Pathology, College of Oriental medicine, Woosuk University) ;
  • Jung Han Sol (Department of Pathology, College of Oriental medicine, Woosuk University) ;
  • Kwon Jin (Department of Health Administration, Kunjang College) ;
  • Oh Chan Ho (Division of Biotechnology, Woosuk University) ;
  • Lee Kwang Gyu (Department of Pathology, College of Oriental medicine, Woosuk University)
  • 이원범 (우석대학교 한의과대학 병리학교실) ;
  • 정한솔 (우석대학교 한의과대학 병리학교실) ;
  • 권진 (군장대학 보건행정과) ;
  • 오찬호 (우석대학교 생명공학부) ;
  • 이광규 (우석대학교 한의과대학 병리학교실)
  • Published : 2002.04.01
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Abstract

The purpose of this research was to investigate the immunoregulatory effect, apoptosis of L 1210 leukemia cells of Comus officinalis Sieb.et Zucc. The proliferation of cultured splenocytes and thymocytes were enhanced by the addition of SSY. Splenic, thymic and mesenteric lymph node-T lymphocytes, especially TH cells was significantly increased in SSY-administered (p.o. for 7 days) mice. SSY treatment induced the apoptosis of L1210 mouse leukemia cells. In addition, SSY accelerated the phagocytic activity and nitric oxide production in peritoneal macrophages. These results suggest that SSY have an immuno-regulatory property and anti-cancer effect.

Keywords

References

  1. "Hayward" Riv. Frutticoltura v.57 no.4 Valutazione de selezioni maschilidi actinidia come impollinatori per la cv. Testolin, R.;Cipriani, G.;Gottardo;L and Costa. G.
  2. Chinese herbal medicine, Materia Medica. Bensky, D;Andrew, G.
  3. A chinese herbal reference for the west v.1;2 Holmes, P.;Remedies, J.
  4. Cell and Environment v.8 Extraorgan freezing in wintering flower buds of Cornus officinalis Sieb. Et Zucc. Plant Ishikawa, M.;Sakai, A. https://doi.org/10.1111/j.1365-3040.1985.tb01407.x
  5. J. Immunol. methods v.65 Rapid colorimetric assay for cellular growth and survival application to proliferation and cytotoxic assays. Mosmann, T. https://doi.org/10.1016/0022-1759(83)90303-4
  6. Cell Prolif. v.24 Evaluation of glucocorticoid-induced DNA fragmentation in mouse thymocytes by flow cytometry. Telford, W.G.;King, L. E.;Fraker, P.J. https://doi.org/10.1111/j.1365-2184.1991.tb01173.x
  7. Biochimica et Biophysica Acta v.1133 Analysis and discrimination of necrosis and apoptosis (psrogrammed cell death) by multiparameter flow cytometry. Dive, C.;Gregory, C.D.;Phipps, D.J.;Evans, D.L.;Milner, A.E.;Wyllie, A.H. https://doi.org/10.1016/0167-4889(92)90048-G
  8. Nature v.284 Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Willie, A.H. https://doi.org/10.1038/284555a0
  9. J. Exp. Med. v.181 Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo. Zamzami, N.;Marchetti, P.;Castedo, M.;Zanin, C.;Vayssiere, J.L.;Petit, PP.X.;Kroemer, G. https://doi.org/10.1084/jem.181.5.1661
  10. Biol. Pharm. Bull. v.17 no.5 Nitric oxide production in mouse peritoneal macrophage enhanced with glycyrrhizin. Kondo, Y.;Takano, F. https://doi.org/10.1248/bpb.17.759
  11. J. Immunol. Methods v.174 Chemiluminescence and nitrite determinations by the MALU macrophage cell line. Boudard, F.;Vallot, N.;Cabaner, C;Bastide, M. https://doi.org/10.1016/0022-1759(94)90030-2
  12. Cellular and molecular immunology v.2 Abbas, A.K.;Lichman, A.H.;Poper, J.S.
  13. Immunology Today v.13 Nitric oxide; a pathogenic factor in autoimmunity. Kolb, H.;Kolb-Bachofen, V. https://doi.org/10.1016/0167-5699(92)90118-Q
  14. J. Immunol. Methods v.112 Measurement of phagocyte chemiluminescence in a microtiter plate format. Blair, A.L.;Cree, I.A.;Beck, J.S.;Hating, M.J.G. https://doi.org/10.1016/0022-1759(88)90352-3
  15. Cell v.88 Apoptosis by death factor. Nagata, S. https://doi.org/10.1016/S0092-8674(00)81874-7
  16. Radiotherapy & Oncology v.33 no.1 Apoptosis and a re-investigation of the biologic basis for cancer therapy. D'Amico, A.V.;McKenna, W.G. https://doi.org/10.1016/0167-8140(94)90079-5
  17. Br. J. Cancer v.26 Apoptosis, a basic biological phenomenon with wider implications in tissue kinetics. Kerr, J.F.K.;Wyllie, A.H.;Currie, A.H. https://doi.org/10.1038/bjc.1972.33
  18. Int. Rev. Cytol. v.68 The significance of apoptosis. Willie, A.H.;Kerr, J.F.R.;Currie, A.R. https://doi.org/10.1016/S0074-7696(08)62312-8
  19. J. Immunol. Methods v.139 Rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. Nicoletti, I.;Migliorati, G.;Pagliacci, M.C.;Grignani, G.;Riccardi, C.A. https://doi.org/10.1016/0022-1759(91)90198-O