Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Jingansikpung-tang Water Extract on LDH Activity of Cultured Spinal Sensory Neurons Damaged by GO

진간식풍탕 전탕액이 GO에 의해 손상된 배양 척수감각신경세포의 LDH 활성도에 미치는 영향

  • Park Kwang Su (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Kwon Kang Beam (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Seong Eun Kyung (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Song Yong Sun (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Ryu Do Gon (Department of Physiology, College of Oriental Medicine, Wonkwang University)
  • 박광수 (원광대학교 한의과대학 생리학교실) ;
  • 권강범 (원광대학교 한의과대학 생리학교실) ;
  • 성은경 (원광대학교 한의과대학 생리학교실) ;
  • 송용선 (원광대학교 한의과대학 재활의학과) ;
  • 류도곤 (원광대학교 한의과대학 생리학교실)
  • Published : 2002.06.01
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Abstract

To evaluate the effect of Jingansikpung-tang(JST) water extract on cultured mouse spinal sensory neuron which was inhibited by glucose oxidase(GO)-induced cytotoxicity, MTT and LDH activity assay were carried out after the cultured mouse spinal sensory neuron were pre-incubated with various concentrations of JST extract for 3 hours prior to exposure of GO. The results obtained were as follows: GO, a oxygen radical, decreased the survival rate of the cultured mouse spinal sensory neuron cells on MTT assay. JST water extract have efficacy of decreasing LDH activity increasing by GO in cultured mouse spinal sensory neuron. From above the results, it is concluded that JST water extract has marked efficacy as a treatment for the damages caused in the GO-mediated oxidative process.

Keywords

References

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