Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effect of Kamidaebo-tang on Murine Peritoneal Macrophages

가미대보탕이 생쥐의 복강 Macrophages에 미치는 영향

  • Song Jung Mo (Department of Oriental Medicine, Woosuk University) ;
  • Oh Chan Ho (College of Science and Technology, Woosuk University) ;
  • So June No (College of Science and Technology, Woosuk University) ;
  • Kim Dae Keun (College of Pharmacy, Woosuk University) ;
  • Eun Jae Soon (College of Pharmacy, Woosuk University)
  • Published : 2002.10.01
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Abstract

The purpose of this research was to investigate the effects of Kamidaebo-tang water extract (KDT) on murine peritoneal macrophages. KDT (50 or 250 mg/kg) was administerd p.o. once a day for 7 days to mice. KDT increased the production of tumor necrosis factor-α and nitric oxide from murine peritoneal macrophages, but decreased the production of interleukin-1β. Also, KDT enhanced the production of lucigenin chemiluminescence from peritoneal macrophages. These results suggest that KDT enhances the non-specific immune response via increase of tumor necrosis factor-α and nitric oxide and phagocytic activity from peritoneal macrophages.

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