Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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A Comparative Study of action Mechanism on the Cerebral Hemodynamics by Cheonghunhwadam-tang and Cheonghunhwadam-tang adding Gastrodiae Rhizoma in Rats

청훈화담탕 및 청훈화담탕가천마에 의한 뇌혈류역학의 작용기전에 대한 비교연구

  • Jeong Hyun Woo (Department of pathology, College ,of Oriental Medicine, Dongshin University) ;
  • Lee Geum Soo (Department of pathology, College ,of Oriental Medicine, Dongshin University) ;
  • Yang Gi Ho (Department of pathology, College ,of Oriental Medicine, Dongshin University)
  • 정현우 (동신대학교 한의과대학 병리학교실) ;
  • 이금수 (동신대학교 한의과대학 병리학교실) ;
  • 양기호 (동신대학교 한의과대학 병리학교실)
  • Published : 2002.12.01
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Abstract

Cheonghunhwadam-tang(CHT) have been used in oriental medicine for many centuries as a therapeutic agent of vertigo by wind, fire and phlegm. CHTGR was CHT adding Gastrodae Rhizoma. The effects of CHTGR on the regional cerebral blood flow(rCBF) and mean arterial blood pressure(MABP) is not known. A comparative Study of action-mechanism of CHT and CHTGR on the cerebral hemodynamics is not known too. Therefore, purpose of this Study was to investigate effects of CHT and CHTGR on the rCBF and MABP, compare action-mechanism of CHT and CHTGR on the rCBF and MABP. The changes of rCBF and BP was determinated by Laser-Doppler Flowmetry(LDF). The results were as follows ; CHT extract was increased rCBF in a dose-dependent, but was not changed MABP compared with CHT non-treated group. CHTGR extract was decreased rCBF and MABP compared with CHTGR non-treated group in a dose-dependent. Action of CHT is not related with adrenergic β-receptor, cyclooxygenase and guanylate cyclase, but action of CHTGR is related with guanylate cyclase.

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