Mycobiology

The Korean Society of Mycology (한국균학회)
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Antifungal Activity of 4',7-Dimethoxyisoflavone Against Some Fungi

  • Pandey, M.K. (Department of Mycology and Plant Pathology, Institute of Agricultural Sciences, Banaras Hindu University) ;
  • Pandey, R. (Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University) ;
  • Singh, V.P. (Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University) ;
  • Pandey, V.B. (Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University) ;
  • Singh, U.P. (Department of Mycology and Plant Pathology, Institute of Agricultural Sciences, Banaras Hindu University)
  • Published : 2002.03.31
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Abstract

The 4',7-dimethoxyisoflavone was isolated from the leaves of Albizzia lebbeck for the first time. This flavonoid showed antifungal activity against some plant pathogenic fungi tested in vitro, e.g., Alternaria melongenae, A. brassicicola, A. brassicae, Curvularia maculans, C. pallescens, C. lunata, Curvularia species, Colletotrichum species, Helminthosporium penniseti and H. speciferum. The sensitivity of different fungi to this chemical varied considerably. A. brassicae was most sensitive as complete inhibition of germination was observed in all the concentrations(100 to 1000 ppm) of the chemical. Similar effect on H. speciferum and Curvularia species was also recorded at 500 ppm, whereas H. penniseti did not germinate at 250 ppm. A. melongenae and A. brassicicola also did not germinate at 1000 ppm while 750 ppm was inhibitory to C. lunata and C. maculans. Germination in almost all fungi was significantly inhibited at each concentration in comparison to control except Curvularia sp. and H. speciferum. Use of 4',7-dimethoxyisoflavone to control some plant diseases under field conditions has been suggested.

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References

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