Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
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The Efficacy of Intracytoplasmic Sperm Injection for Previous Fertilization Failure with Conventional In Vitro Fertilization

고식적 체외수정 시술 시 수정 실패 환자에 대한 세포질내 정자주입술의 효용성

  • Han, Myoung-Seok (Department of Obstetrics and Gynecology, Dong-A University College of Medicine)
  • 한명석 (동아대학교 의과대학 산부인과학교실)
  • Published : 2002.06.30
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Abstract

Objective : This study is to evaluate the efficacy of intracytoplasmic sperm injection (ICSI) for previous fertilization failure with conventional in vitro fetrtilization (IVF), compared with ICSI for male factor. Method: The author analyzed the 3 years of clinical experience with ICSI retrospectively, between the conventional IVF failure group (IVF failure) and male factor group (male factor). Surgically retrieved epididymal or testicular spermatozoa for ICSI were excluded. The IVF failure group was 13 cycles of 6 patients and male factor group was 30 cycles of 15 patients. Results: The fertilization rates of the IVF failure group and male factor group were 63% and 66% respectively (p=0.635). The clinical pregnancy rates of the both group were 23.1% and 26.7% (p=0.804), and that of live birth rates were 15.4% and 13.3% (p=0.858). There were no significant difference between the two groups. Conclusion: The author concluded that ICSI can overcome previous fertilization failure, with the same fertilization and clinical pregnancy rates seen in patients with male factor.

Keywords

References

  1. Nagy Z, Liu J, Cecile J, Silber S, Devroey P, Van Steirteghem A. Using ejaculated, fresh, and frozen-thawed epididymal and testicular spermatozoa gives rise to comparable results after intracytoplasmic sperm injection. Fertil Steril 1995;63: 808-15 https://doi.org/10.1016/S0015-0282(16)57486-X
  2. Van Steirteghem AC, Liu J, Joris H, Nagy Z, Janssenswillen C, Toumaye H, et al. Higher success rate by intracytoplasmic sperm injection than by subzonal insemination. Report of a second series of 300 consecutive treatment cycles. Hum Reprod 1993;8: 1055-60 https://doi.org/10.1093/oxfordjournals.humrep.a138191
  3. Vanderzwalmen P, Barlow P, Nijs M, Bertin G, Leroy F, Schoysman R. Usefulness of partial dissection of the zona pellucida in a human in-vitro fertilization programme. Hum Reprod 1992; 7: 537-44 https://doi.org/10.1093/oxfordjournals.humrep.a137686
  4. Tomas C, Orava M, Tuomivaara L, Martikainen H. Low pregnancy rate is achieved in patients treated with intracytoplasmic sperm injection due to previous low or failed fertilization in in-vitro fertilization. Hum Reprod 1998; 13:65-70 https://doi.org/10.1093/humrep/13.1.65
  5. Miller KF, Falcone T, Goldberg JM, Attaran M. Previous fertilization failure with conventional in vitro fertilization is associated with poor outcome of intracytoplasmic sperm injection. Fertil Steril 1998; 69: 242-5 https://doi.org/10.1016/S0015-0282(97)00465-2
  6. Miller KF, Falcone T, Goldberg JM, Attaran M. Previous fertilization failure with conventional in vitro fertilization is associated with poor outcome of intracytoplasmic sperm injection. Fertil Steril 1998; 69: 242-5 https://doi.org/10.1016/S0015-0282(97)00465-2
  7. Svalander P, Forsberg AS, Jkobsson AH, Wikland M. Factorsof importance for the establishment of a successful program of intracytoplasmic sperm injection for male infertility. Fertil Steril 1995; 63: 828-37 https://doi.org/10.1016/S0015-0282(16)57489-5
  8. Palermo G, Joris H, Devroey P, Van Steirteghem AC. Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte. Lancet 1992; 340: 17-8 https://doi.org/10.1016/0140-6736(92)92425-F
  9. Tesarik J, Sousa M. More than 90% fertilization rates after intracytoplasmic sperm injection and artificial induction of oocyte activation with calcium ionophore. Fertil Steril 1995; 63: 343-9 https://doi.org/10.1016/S0015-0282(16)57366-X
  10. Gabrielsen A, Petersen K, Mikkelsen AL, Lindenberg S. Intracytoplasmic sperm injection dose not overcome an oocyte defect in previous fertilization failure with conventional in-vitro fertilization and normal spermatozoa. Hum Reprod 1996; 11: 1963-5 https://doi.org/10.1093/oxfordjournals.humrep.a019525
  11. Lipitz S, Rabinovici J, Goldenberg M, Bider D, Dor J, Mashiach S. Complete failure of fertilization in couples with mechanical infertility: implications for subsequent in vitro fertilization cycles. Fertil Steril 1994;61: 863-6 https://doi.org/10.1016/S0015-0282(16)56697-7