A Study on the Immune Modulation and Hepatoprotection of Gamichunggan-tang (GCT)

가미청간탕의 간보호 및 면역조절효과

  • 손창규 (대전대학교 한의과대학 간계내과 교실) ;
  • 한성수 (대전대학교 한의과대학 간계내과 교실) ;
  • 조종관 (대전대학교 한의과대학 간계내과 교실)
  • Published : 2002.06.01

Abstract

Objectives : This study was to examine the efficacy of GCT on the hepatoprotective effect in the liver function and immune octivity. Methods : The experiment to investigate the hepatoprotective effect of GCT on the liver damage was conducted with D-galactosamine. The experiments to verify the effects of GCT on the immune activity were conducted by carbon clearance assay, plaque-forming cell SRBC assay of IgM, lymphoproliferation assay of T and B cells, and adherence and phagocytosis of mocrophages. Results: In the damage of liver induced by D-galactosamine, GCT carried hepatoprotective effect on AST. In carbon clearance assay GCT showed significant effect on phagocytosis of Kuffer cells. In the plaque-forming cell assay, GCT improved the formation of IgM. In the lymphoproliferation assay, GCT activated the formation of T and B lymphocytes. In macrophages, GCT activated adherence and phagocytosis. Conclusion : Though further study is needed, our findings suggest that GCT could be recommended as hepatoprotector and immune modulator for liver disease.

Keywords

References

  1. 간계내과학 김병운;우홍정;김덕호;강병기;임재훈;강윤호;조종관;최서형;장문석
  2. 조직학 정일천
  3. 병리학 손태중
  4. 臟腑辨證論治 김완희;최달영
  5. 精校黃帝內經靈樞 洪元植
  6. HARRISON'S 내과학 Isselbacher KJ
  7. 96년도 사망원인통계결과 통계청
  8. 大韓韓醫學會誌 v.21 no.1 인진분획물이 인체 간세포의 TGF 1-induced apoptosis에 미치는 영향 이지현;이장훈;우홍정
  9. Medical Immunology Stities DP;Terr AI;Parsolow TG
  10. 大田大學校 韓醫學硏究所 論文集 v.6 生肝健脾湯을 이용한 慢性肝炎 35例에 대한 臨床分析 곽경규;김연진;조종관
  11. The Journal of Cell Biology v.43 High-yield preparation of isolated rat liver parenchymal cells Berry MN;Friend DS
  12. C. R. Soc. Biol. v.148 Etude quantitative du l activite granulopexigue du systeme reticulo-endothelial chez al souns Biozzio G;Benacerraf B;Stiffel C;Halpern BN
  13. Methods in Immunotoxicology Evaluation of Immune Funcions in Toxicology Luster MI;Dean JH;Moore JA
  14. 黃帝內經素問今釋 汪機
  15. 漢藥臨床應用 李尙仁;安德均;辛民敎;盧昇鉉;李暎鍾;金先熙
  16. Ethnopharmacology v.70 Protective effects of bergenin the major constituent of Mallotus japonicus on D-galactosamine-intoxicated rat hepatocytes Lim HK;Kim HS;Chung MW;Kim YC
  17. Immunology Roitt I;Brostoff J;Male D