Journal of Photoscience
- Volume 9 Issue 2
- /
- Pages.521-523
- /
- 2002
- /
- 1225-8555(pISSN)
A Spectral Comparison Study of PDT Drugs - ALA and ALA-Hexyl ester
- Yao, Chen-Ji (Department of Physics, Fudan University) ;
- Peng Qian (Department of Pathology, Institute for Cancer Research, University of Oslo) ;
- JodI H-J (Department of Physics, Kaiserslautern University)
- Published : 2002.08.01
Abstract
5-aminolevulinic acid (ALA) has been used to stimulate endogenous protoporphyrin IX (PpIX) in tumor and then initiate PDT. Recently, ALA-Hexyl ester (He-ALA) was found much effective than ALA on producing PpIX in cancer cells. To clarify the transportation mechanism of ALA and He-ALA, the detection of them is the important step. ALA and its derivatives all don't emit fluorescence, so the Raman spectroscopy was used here for the direct detection of ALA and He-ALA. The results showed that ALA and He-ALA have the common strong Raman peaks at 2930, 2950 CM