Journal of Photoscience
- Volume 9 Issue 2
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- Pages.515-517
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- 2002
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- 1225-8555(pISSN)
Detection of 1270 nm Emission from Singlet Oxygen due to Photodynamic Therapy in vitro and in vivo.
- Hirano, Toru (Photon Medical Research Center, Hamamatsu University School of Medicine) ;
- Kohno, Eiji (Photon Medical Research Center, Hamamatsu University School of Medicine) ;
- Ito, Toshiaki (Hamamatsu Photonics KK) ;
- Okazaki, Shigetoshi (Hamamatsu Photonics KK) ;
- Hirohata, Toru (Hamamatsu Photonics KK) ;
- Niigaki, Minoru (Hamamatsu Photonics KK) ;
- Kageyama, Kazumi (Hamamatsu Photonics KK) ;
- Miyaki, Sueo (Hamamatsu Photonics KK)
- Published : 2002.08.01
Abstract
Photodynamic therapy (PDT) is a cancer treatment modality which utilizes the cytotoxicity of the active singlet oxygen derived from irradiation of a tumor accumulated photosensitizer. As the oxygen in the singlet state radiates an emission of 1270nm wavelength when it decays to the triplet state, detection of the emission helps us to understand the mechanism of PDT or to evaluate photosensitizers. We detected the 1270nm emission from photosensitizers Photofrin and ATX-SI0 in vitro and in vivo by means of high sensitive NIR detectors. We obtained the maximum amount of singlet oxygen at irradiation wavelength of 665-670nm from a HeLa tumor in a nude mouse which is injected with ATX-S10.