Journal of Photoscience
- Volume 9 Issue 2
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- Pages.178-181
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- 2002
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- 1225-8555(pISSN)
The Synthetic Approaches to Modify Methyl (Pyro)pheophorbide a
- Wang, Jin-Jun (Department of Applied Chemistry, Yantai University) ;
- Han, Guang-Fan (Medical College, Beihua University) ;
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Lee, Jong-Cheol
(Medicinal Science Division, Korea Research Institute of Chemical Technology) ;
- Shim, Young-Key (Medicinal Science Division, Korea Research Institute of Chemical Technology)
- Published : 2002.08.01
Abstract
Pyropheophorbide and pheophorbide-photosensitizers as chlorin analogues are promising new compounds for PDT because the chlorin analogues are activated with much longer red light at > 670nm and produce less long-term normal tissue phototoxicity than Photofrin. The various chlorin derivatives can be obtained by moditying peripheral substituted group among which meso-H, vinyl group and exocyclic ring are the most active positions. These characteristics prompted us to introduce various groups for constructing modified pyropheophorbide and pheophorbide a compounds. A stereospecific introduction of various double bonds at 3-position was performed to methylpheophorbide a to give a long hydrophobic moiety and cyclic derivatives. Chlorin-C
Keywords
- photodynamic therapy;
- porphyrins;
- chlorines;
- (pyro)pheophorbide a;
- photosensitizer;
- Spirulina;
- tumor