Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Constituents of the Fruits and Leaves of Euodia daniellii

  • Yoo, Sang-Woo (Natural Products Research Institute and College of Pharmacy, Seoul National University) ;
  • Kim, Ju-Sun (Natural Products Research Institute and College of Pharmacy, Seoul National University) ;
  • Kang, Sam-Sik (Natural Products Research Institute and College of Pharmacy, Seoul National University) ;
  • Son, Kun-Ho (Department of Food and Nutrition, Andong National University) ;
  • Chang, Hyeun-Wook (College of Pharmacy, Yeongnam University) ;
  • Kim, Hyun-Pyo (College of Pharmacy, Kangwon National University) ;
  • Bae, Ki-Hwan (College of Pharmacy, Chungnam National University) ;
  • Lee, Chong-Ock (Korea Research Institute of Chemical Toxicology)
  • Published : 2002.12.01
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Abstract

Four flavonoid glycosides, flavaprin (7), evodioside B (8), vitexin (11), and hesperidin (12), as well as the coumarins bergapten (1), xanthotoxin (2), and isopimpinellin (3), the lignan simplexoside (10), the steroids ${\beta}-sitosterol$ (4) and daucosterol (5), the limonoids isolimonexic acid (6) and limonin (9), and uracil (13) and myo-inositol (14) have been isolated from Euodia daniellii. The structures of these compounds were established from spectral data. Among the isolates, bergapten showed cyclooxygenase-2 inhibitory activity with an $IC_{50}$ value of $6.2{\;}{\mu\textrm{g}}/ml. Flavonoids isolated from this plant exhibited no cytotoxic activity against the human tumor cell lines, A549, SKOV-3, SKMEL-2, XF498, and HCT15.

Keywords

References

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