Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Antidiarrheal Effect of LacteolTM-Loperamide Combination on Castor oil-induced Mice Model

  • Hwang, Se-Hee (Central Research Laboratories, Dong Wha Pharm. Ind. Co. Ltd.) ;
  • Sung, Hee-Jin (Central Research Laboratories, Dong Wha Pharm. Ind. Co. Ltd.) ;
  • Chung, Yong-Ho (Central Research Laboratories, Dong Wha Pharm. Ind. Co. Ltd.) ;
  • Ryu, Jei-Man (Central Research Laboratories, Dong Wha Pharm. Ind. Co. Ltd.) ;
  • Seong, Seung-Kyoo (Central Research Laboratories, Dong Wha Pharm. Ind. Co. Ltd.)
  • Published : 2002.12.01
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Abstract

The goal of this study was to evaluate the antidiarrheal efficacy of $Lacteol^{TM}$-loperamide combination against the mouse model of secretory diarrhea. Secretory dirrhea was induced in mice by p.o. administration of castor oil (0.3 ml). Antidirrheal effects of $Lacteol^{TM}$-loperamide combination were compared with each individual component. $Lacteol^{TM}$-loperamide combination was the most potent among these agents, eliminating diarrhea in 100% of mice at a dose 1360/4 mg/kg (Lacteol/loperamide, respectively). In this study, we also measured changes of bodyweight as another indicator of the dirrhea, based on the assumption that lower bodyweight loss represented reduced fecal passage. The bodyweight loss of $Lacteol^{TM}$-loperamide combination administered group was 4 times lower than that of vehicle control. These findings indicate that $Lacteol^{TM}$-loperamide combination may be more potent than individual component in its antidiarrheal action, so we are going to challenge this combination for further study and clinical evaluation.

Keywords

References

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