Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Effects of Ginseng Total Saponin on [3H]DAGO Bindings of Opioid μ-Receptors

  • Oh, Ki-Wan (Department of Pharmacology, College of Pharmacy, Chungbuk National University) ;
  • Lim, Hwa-Kyung (Korea Food and Drug Administration) ;
  • Park, Cheol-Beum (Department of Pharmacology, College of Pharmacy, Chungbuk National University) ;
  • Shin, Im-Chul (Department of Pharmacology, College of Pharmacy, Chungbuk National University) ;
  • Hong, Jin-Tae (Department of Pharmacology, College of Pharmacy, Chungbuk National University)
  • Published : 2002.12.01
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Abstract

Crude synaptic membrane fractions from the frontal cortex, striatum, brain stem and whole brain of rat were prepared to assay the effects of ginseng total saponin (GTS) on [$^3$H]DAGO bindings of the opioid $\mu$-receptors. Scatchard plots analysis binding data demonstrated that GTS (0.1 mg/ml) decreased the affinity of specific [$^3$H]DAGO bindings without changes in B$\_$max/ in the frontal cortex and striatum. On the other hand, GTS did not affect the [$^3$H]DAGO bindings iii the brain stem and whole brain. These results suggest that the regulation of [$^3$H]DAGO bindings by GTS may play roles in the change of the pharmacological responses of $\mu$-opioids.

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References

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