랫드에 대한 G. bimaculatus의 급성경구독성시험

Acute Oral Toxicity of G. bimaculatus in Rats

  • 김인선 (성균관대학교 약학대학 독성학교실) ;
  • 안미영 (농업과학기술원 잠사곤충부) ;
  • 류강선 (농업과학기술원 잠사곤충부) ;
  • 이병무 (성균관대학교 약학대학 독성학교실)
  • 발행 : 2002.12.01

초록

This study was carried out to investigate the acute toxicity of G. bimaculatus in Sprague-Dawley rats. G. bimaculatus was administered orally at doses of 8, 40, 200, 1000 and 5000 mg/kg. in this study, number of deaths, clinical sign, body weights, and pathological examination were investigated for 14 days after administration of G. bimaculatus. The results indicate that G. bimaculatus did not show any toxic effect in rats and oral $LD_{50}$ value was over 5000 mg/kg in Sprague-Dawley rats.

키워드

참고문헌

  1. Fund. Appl. Toxicol. v.5 An up-and-down procedure for acute toxicity testing Bruce,R.D. https://doi.org/10.1016/0272-0590(85)90059-4
  2. J. Appl. Pharmacol. v.2 Acute subcutaneous toxicity study of banaron cream in rats Cho,D.H.;Hwang,S.J.;Lee,W.Y.;Lee,J.Y.;Yoon,H.J.;Moon,B.W.
  3. J. Appl. Pharmacol. v.2 Acute oral toxicity studies of WHS-1 and WHS-2 in rats Cho,D.H.;Hwang,S.J.;Lee,W.Y.;Lee,J.Y.;Yoon,H.J.;Moon,B.W.
  4. Arch. Toxicol. v.54 A new approach to practival toxicity testing Lorke,D. https://doi.org/10.1007/BF01234480
  5. Toxicity test guideline for safety evaluation of drugs for human use. No. 94-3 Korea National Institute of Safety Research
  6. J. Toxicol. Sci. Jpn. v.17 Studies on single-dose toxicity of hydrophobically modified hydropropyl methylcellulose in rats Obara,S. https://doi.org/10.2131/jts.17.13
  7. J. Applied Pharmacol. v.6 Subacute oral Toxicity of DWP-311 in Sparague-Dawley Rats Kim,H.S.;Kwack,S.J.;Chun,S.A.;Han,H.S.;Park,H.S.;Ahn,M.Y.;Bae,K.H.;Lee,B.M.
  8. Korean J. Toxicol. v.12 Acute oral toxicity of KDRD-010 in Rats Kwack,S.J.;Kim,H.S.;Chun,S.A.;Lim,S.Y.;Park,H.S.;Hong,C.H.;Choi,B.C.;Lee,B.M.
  9. J. Toxicol. Sci. Jpn. v.17 Single dose toxicity studies of suplatast tosilate (IPD-1151T) Yamashita,K.;Nakano,S.;Kuwata,M.;Yada,H.;Irimura,K.;Morinaga,H.;Morita,K.
  10. Arch. Toxicol. v.47 Significance of the $LD_{50}$ test for toxicological evaluation of chemical substance Zbinden,G.;Flury Roversi,M. https://doi.org/10.1007/BF00332351