Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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In Vitro Bactericidal and Anticancer Activity of New Metabolite, ARK42, Isolated from Aspergillus repens K42

  • Park, Je-Won (Graduate School of Biotechnology, Korea University) ;
  • Song, Beom-Seok (Graduate School of Biotechnology, Korea University) ;
  • Ryu, Do-Jin (Department of Food science and Technology, University of Nebraska) ;
  • Lee, Chan (Department of Food Science and Technology, Chung-Ang University) ;
  • Kim, Young-Bae (Graduate School of Biotechnology, Korea University)
  • Published : 2002.12.01
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Abstract

A novel antibacterial metabolite, ARK42, was elated from a xerophilic fungal strain K42, and Identified as Aspergillus repens based on its morphological characteristics. The metabolite exhibited antibacterial activities towards Staphylococcus aureus, Bacillus cereus, and Pseudomonas aeruginosa, with MICs of 25, 12.5, and $3.125{\mu}g/ml$, respectively, and killed Pseudomonas aeruginosa with minimal bactericidal concentration (MBC) of $12.5{\mu}g/ml$. Furthermore, anticancer activities were demonstrated against human colon cancer DLD- 1 and lung cancer LXFL529 cells with an $IC_50$ of 10 and $1{\mu}g/ml$, respectively.

Keywords

References

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