Communications for Statistical Applications and Methods

The Korean Statistical Society (한국통계학회)
권호 표지
DOI QR코드

DOI QR Code

Nonparametric Procedures for Finding Minimum Effective Dose in a One-Way Layout

  • Kim, Hyeonjeong (Department of Biostatistics, The Catholic University of Korea) ;
  • Kim, Dongjae (Department of Biostatistics, The Catholic University of Korea)
  • Published : 2002.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

When the lowest dose level compared with zero-dose control has significant difference in effect, it is referred as minimum effective dose (MED). In this paper, we discuss several nonparametric methods for finding MED using updated rank at each sequential test step in small sample size and suggest new nonparametric procedures based on placement. Monte Carlo Simulation is adapted to compare power and Familywise Error Rate(FWE) of the new procedures with those of discussed nonparametric tests for finding MED.

Keywords

References

  1. Communications in Statistics-Simulation and Computation v.22 Nonparametric comparisons of umbrella pattern treatment effects with a control in a one-way layout Chen, Y. I. https://doi.org/10.1080/03610919308813121
  2. Biometrics v.49 Nonparametric procedures for comparing umbrella pattern treatment effects with a control in a one-way layout Chen, Y. I.;Wolfe, D. A. https://doi.org/10.2307/2532558
  3. Biometrics v.55 Nonparametric identification of the minimum effective dose Chen, Y. I. https://doi.org/10.1111/j.0006-341X.1999.01236.x
  4. Journal of the American Statistical Association v.76 K-sample rank tests for umbrella alternatives Mack, G. A.;Wolfe, D. A. https://doi.org/10.2307/2287064
  5. Journal of the American Statistical Association v.77 A class of distribution-free two-sample tests based on placements Orban, J.;Wolfe, D. A. https://doi.org/10.2307/2287734
  6. Journal of the American Statistical Association v.84 Contrasts for identifying the minimum efective dose Ruberg, S. J. https://doi.org/10.2307/2289672
  7. Biometrics v.33 A non-parametric equivalent of Williams' test for contrasting increasing dose levels of a treatment Shirley, E. https://doi.org/10.2307/2529789
  8. Biometrics v.52 Multiple test procedures for dose finding Tamhane, A. C.;Hochberg, Y.;Dunnett, C. W. https://doi.org/10.2307/2533141
  9. Biometrics v.42 A note on Shirley's nonparametric test for comparing several dose levels with a zero-dose control Williams, D. A. https://doi.org/10.2307/2531254