Preventive Nutrition and Food Science

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Antibacterial Activity of Oleanolic Acid from Physalis angulata against Oral Pathogens

  • Hwang, Jae-Kwan (Department of Biomaterials Science and Engineering & Bioproducts Research Center, Yonsei University) ;
  • Shim, Jae-Seok (Department of Biomaterials Science and Engineering & Bioproducts Research Center, Yonsei University) ;
  • Park, Kyung-Min (Department of Biomaterials Science and Engineering & Bioproducts Research Center, Yonsei University) ;
  • Chung, Jae-Youn (Department of Biomaterials Science and Engineering & Bioproducts Research Center, Yonsei University)
  • Published : 2002.06.01
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Abstract

A methanol extract of Physalis angulata exhibited in vitro antibarterial activity against oral pathogens such including Streptococcus mutans and Porphyromonas gingivalis. The methanol extract of Physalis angulata was further fractionated with ethyl acetate, n-butanol and water, in which the ethyl acetate fraction exclusively showed antibacterial activity. An active antibacterial compound from the ethyl acetate fraction was purified to a single compound using silica gel column chromatography and identified as oleanolic acid by $^{13}$ C-NMR, $^1$H-NMR and EI-MS. MIC of oleanolic acid against S. mutants and p. gingivalis were determined to be 50 and 25 ug/mL, respectively. The Antibacterial activity of oleanolic acid from Physalis angulata suggested that it has potential as an anticarcinogenic and antiperiodontic ingredients in various foods and oral care products.

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