Development of Medium for Griseofulvin Production: Part I. Screening of Medium Constituents Using the Plackett-Burman Experimental Design

  • Venkata, Dasu-V. (Biotechnology Research Centre, Department of Chemical Engineering, Indian Institute of Technology-madras) ;
  • Panda, T. (Biotechnology Research Centre, Department of Chemical Engineering, Indian Institute of Technology-Madras) ;
  • Chidambaram, M. (Biotechnology Research Centre, Department of Chemical Engineering, Indian Institute of Technology-Madras)
  • Published : 2002.06.01

Abstract

The Plackett-Burman experimental design was employed to evaluate the relative importance of medium constituents of each medium for enhanced griseofulvin production by Penicillium griseofulvum MTCC 1898 and Penicillium griseofulvum MTCC 2004. It was found that the medium constituents, sucrose, $K_2HPO_4,\;NaNO_3,\;and\;FeSO_4{\cdot}7H_2O$, significantly influenced the griseofulvin production by Penicillium griseofulvum MTCC 1898. In the case of Penicillium griseofulvum MTCC 2004, lactose, glucose, and $MnSO_4{\cdot}H_2O$ significantly influenced the griseofulvin production.

Keywords

References

  1. Antimicrob. Agents Chemother v.59 Factors affecting the biosynthesis of griseofulvin Bayan, A.P.;U.F. Unger;W.E. Brown
  2. Brit. Mycol. Soc. Trans. v.32 Curling factor, a substance causing abnormal development of fungal hyphae produced by Penicillium janczewskii Brain, P.W.
  3. J. Phar. Pharmcol. v.15 A rapod method for the determination of griseofulvin in fermentation broth Holbrook, A.;F. Bailey;G.M. Bailey https://doi.org/10.1111/j.2042-7158.1963.tb11222.x
  4. J. Ferment. Bioeng. v.85 Effect of nitrogen sources on the levels of aldose reductase and xylitol dehydrogenase activities in the xylose fermenting yeast Candida tenuis Kerm, M.;B. Nidetzky;K.D. Kulbe;D. Haltrich https://doi.org/10.1016/S0922-338X(97)86767-0
  5. Bioproc. Eng. v.19 Screening and selection of media components for lactic acid production using Plackett-Burman design Krishnan, S.;S.G. Prapulla;D. Rajalakshmi;M.C. Mishra;N.G. Karanth https://doi.org/10.1007/PL00009003
  6. J. Chem. Soc. Griseofulvin Ⅶ. Dechlorogriseofulvin Macmillan, J. https://doi.org/10.1039/jr9530001697
  7. USSR Pat. 412,785 Malkov, M.A.;V.M. Fishman;V.A. Tsygano;N.M. Matokhina;N.F. Susidko;G. Kleiners;N.V. Soloveva
  8. Biochem. J. v.33 The biochemistry of micro-organixms LX. Griseofulvin, (TEX)$C_17H_17O_6Cl$(/TEX), a vetabolic product of Penicillium griseofulvum Dierckx Oxford, A. E.;H. Raisytick,;P. Simonart https://doi.org/10.1042/bj0330240
  9. Biometrica v.33 The dexign of optimum multifactorial experiments Plackett, P. L.;J. P. Burman https://doi.org/10.1093/biomet/33.4.305
  10. Biotechnology VCH Verlagsgesellschaft mbh Griseofuvin Rehm, H.J.;G. Reed.;Pape, H.(ed.);H. J. Rehm(ed.)
  11. Brit. Pat. 784,618 Griseofulvin Rhodes, A.;R. Crosse;T. P. Ferguson;D. L. Fletcher
  12. Proc. Biochem. v.27 Medium development for xanthan production Roseiro,J.C.;M.E. Esgalhado;M.T.Amaral Collaco;A. N. Emery https://doi.org/10.1016/0032-9592(92)87005-2
  13. J. Biochem. v.7 Production of griseofulvin by Penicillium griseofulvum Saeed, M;A. Khaliq;H. Tanwirul
  14. Bioproc. Eng. v.18 Comparative analysis of optimal endogluconase production by Trichoderma reesei and intergeneric fusants of Trichoderma reesei/ Saccharomyces cerevisiae Sinha, J.;T. Panda.
  15. Biotechnol. Tech. v.8 Statishical optimization of production medium for β-1,3-gluconase synthesis by Trichoderma harzianum Theodore, K.;T. Panda. https://doi.org/10.1007/BF00154307
  16. Bioproc. Eng. v.22 optimization of microbiological parameters for enhanced griseofulvin production using response surface methodology Venkata Dasu, V.;T. Panda. https://doi.org/10.1007/PL00009099
  17. J. Microbiol. Biotechnol. v.12 Development of medium for griseofulvin production:Optimization of medium constituents using central composite desing Venkata Dasu V.;T. Tanda;M. Chidambaram