YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

A new Cytotoxic Triterpene Hydroperoxide from the Aerial Part of Youngia japonica

뽀리뱅이의 세포독성 트라이테르펜 하이드로퍼옥사이드 성분

  • 이강노 (성균관대학교 약학대학 천연물약품화학 연구실) ;
  • 이원빈 (성균관대학교 약학대학 천연물약품화학 연구실) ;
  • 권학철 (성균관대학교 약학대학 천연물약품화학 연구실) ;
  • 이재훈 (성균관대학교 약학대학 천연물약품화학 연구실) ;
  • 최상운 (한국화학연구소)
  • Published : 2002.02.01
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Abstract

A new cytotoxic triterpene hydroperoxide (3) was isolated from the methylene chloride extract of the aerial part of Youngia japonica together with four known triterpenes (1, 2, 4 and 5). Their structures were identified by means of physico-chemical and spectral data to be $\beta$-amyrin acetate (1), taraxasterol (2), 2l$\alpha$-hydroperoxy-taraxasterol (3), oleanolic acid (4) and ursolic acid (5). Compounds 3 and 5 showed moderate cytotoxicity against five tumor cell lines.

Keywords

References

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