Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
권호 표지

Neuropretective effect of Kupunggibodan, Gamisamul-tang and Whangryunhaedok-tang on the ischemia-induced learning and memory deficits by MCAO in the rats

중풍 한방처방전의 효능비교 연구 ; 황련해독탕, 거풍지보단, 가미사물탕이 국소 전뇌허혈에 의한 학습과 기억에 미치는 효과

  • Lee Bom-Bi (Dept. of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Chung Jin-Yong (Dept. of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Kim Sun-Yeou (Dept. of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Kim Ho-Cheol (Dept. of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Kwon Youn-Jun (College of Pharmacy, Catholic University of Daegu) ;
  • Hahm Dae-Hyun (Dept. of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Lee Hae-Jeong (Dept. of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Shim In-Sup (Dept. of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung Hee University)
  • 이봄비 (경희대학교 동서의학대학원 한의학과 침구경락학교실) ;
  • 정진용 (경희대학교 동서의학대학원 한의학과 침구경락학교실) ;
  • 김선녀 (경희대학교 동서의학대학원 한약리학교실) ;
  • 김호철 (경희대학교 동서의학대학원 한약리학교실) ;
  • 권용준 (대구카톨릭대학교 약학대학) ;
  • 함대현 (경희대학교 동서의학대학원 한의학과 침구경락학교실) ;
  • 이혜정 (경희대학교 동서의학대학원 한의학과 침구경락학교실) ;
  • 심인섭 (경희대학교 동서의학대학원 한의학과 침구경락학교실)
  • Published : 2002.06.27
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Abstract

Kupunggibodan(KU), Gamisamul-tang(GA) and Whangryunhaedok-tang(WH) are clinically the most popular prescriptions as an herbal medicine in the treatment of ischemia. In order to compare and evaluate their protective effects on the ischema-induced cognitive deficits by middle cerebral artery occlusion (MCAO), we examined its ability to improve ischemia-induced cell loss and impairements of learning and memory in the Morris water maze and eight-arm radial arm maze. Focal cerebral ischemia produced a marked cell loss, decrease in acetylcholinesterase(AchE) reactivity in the hippocampus, and learning and memory deficits in two behavioral tasks. Pretreatment with WH (100 mg/kg, p.o.) produced a substantial increase in acquisition in the Morris water maze. Pretreatment with KU increased the perfomance of the resention test in the Morris water maze. WH, KU and GA caused a significant improvement in choice accuracy in radial arm maze test. WH was superior to KU and GA in perfomance of the radial arm maze test. Consistent with behavioral data, staining with cresyl violet showed that pretreatments with WH, but not KU and GA significantly recovered the ischemia-induced cell loss in the hippcampal CA1 area. In addition, pretreatments with WH and KU recovered the ischemia-induced reduction of AchE reactivity in the hippocampal CA1 area. These results demonstrated that KU, GA and WH have protective effects against ischimea-induced learning and memory impairments and that the efficacy was the order of WH>KU>GA in tratment of ischemia induced memory deficits. The present studies provide an evidence of KU, GA and WH as putative treatment of vascular dementia. Supported by a fund from the Ministry of Health and Welfare(HMP-00-OO-04-0004), and the Brain Korea 21 Project from Korean Ministry of Education, Korea.

Keywords

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