Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
권호 표지

Anti-anemic Effect of Aqueous Extracts of Fructus schisandrae on Phenylhydrazine-induced Hemolytic Anemia in Female Sprague-Dawley Rats

자성(雌性) 흰쥐에서 phenylhydrazine으로 유발된 용혈성 빈혈에 오미자 약침의 항빈혈효과

  • Shin Hye-Sook (Dept. of Nursing Science, College of Medicine, Kyung Hee University) ;
  • Kim Ee-Hwa (Dept. of Meridian & Acupoint, College of Oriental Medicine, Semyung University) ;
  • Kim Chang-Ju (Dept. of Physiology, College of Medicine, Kyung Hee University)
  • 신혜숙 (경희대학교 의과대학 간호학과) ;
  • 김이화 (세명대학교 한의과대학 경혈학교실) ;
  • 김창주 (경희대학교 의과대학 생리학교실)
  • Published : 2002.03.27
Download PDF
⟨ Previous Next ⟩

Abstract

목적 : 자성(雌性) 흰쥐에서 phenylhydrazine으로 유발된 용혈성 빈혈에 오미자 약침의 항빈혈효과를 알아보기 위해서 적혈구수, hematocrit ratio, hemoglobin, 혈청 철함유량 및 serum total iron binding capacity (TIBC)를 관찰하였다. 방법 : 실험동물은 정상군, 대조군, 250 mg/kg 오미자 투여군 및 500 mg/kg 오미자 투여군으로 총 4개의 군으로 분류하였다. 정상군의 흰쥐는 아무런 처치도 하지 않았고, 대조군은 phenylhydrazine으로 용혈성 빈혈을 유발하였다. 오미자 투여군은 용혈성 빈혈을 유발한 후 7일간 매일 250 mg/kg 및 500 mg/kg의 용량으로 중완혈에 자침하였다. 결과 : 적혈구수, hematocrit ratio 및 hemoglobin은 대조군에서 정상군에 비해 감소한 반면 오미자 투여군은 증가하였다. 혈청 철함유량과 TIBC는 대조군에서 증가하였으나, 오미자 투여군에서는 감소하였다. 이러한 결과로 중완혈에 오미자 자침은 phenylhydrazine으로 유발된 용혈성 빈혈에서 항빈혈효과가 있는 것으로 사려된다.

Keywords

References

  1. Zhonghua Yi Xue Za Zhi v.5 Studies on Fructus schisandrae. I. Its effect on increased SGPT levels in animals caused by hepatotoxic chemical agents. Pao TT;Liu KT;Hsu HF;Sung CY
  2. Chinese Medical Journal v.102 Phramacological actions and clinical use of Fructus schisandrae. Liu GT
  3. Plants Medica v.61 Effect of a lignan-enriched Fructus schisandrae extract on hepatic glutathione status in rats: Protection against carbon tetrachloride toxicity. Ko KM;Ip SP;Poon MKT;Wu SS;Che CT;Ng KH;Kong YC
  4. Japanese Journal of Pharmacology v.69 Enhancement of hepatic glutathion regeneration capacity by a lignan- enriched extract of Fructus Schisandrae in rats. Ko KM;Mak DHF;Li PC;Poon MKT;Ip SP
  5. Yao Xue Xue Bao v.17 Synthesis of schizandrin C analogs. ll. Synthesis of dimethyl-4,4-dimethoxy-5, 6, 5, 6-dimethy-Ienedioxybiphenyl -2, 2- dicarboxylate and its isomers. Xie JX;Zhou J;Zhang CZ;Yang JH;Jin HQ;Chen JX
  6. Chinese Medical Journal v.100 Biphenyl-dimethyl dicarbolflate in treating and preventing hepatitis due to drug poisoning. Yu HQ;Yang XY;Zhang YX;Shi JZ
  7. Drug Development and Indusrial Pharmacy v.25 Solubilization of biphenyl dimethyl dicarboxylate by cosolvency Han SK;Kim GV;Park YH
  8. Phytotherapy Research v.10 Protective effect of a lignan-enrichedektract of Fructus Schisandrae on physicalexercise induced muscle damage in rats. Ko KM;Mak DHF;Li PC;Poon MKT;Ip SP.
  9. Phytotherapy Research v.13 Effects of Fructus schizandrae on cyclohexamide-induced muscle damage in rats. Hsieh MT;Tsai ML;Peng WH;Wu CR
  10. Yao Xue Xue Bao v.22 Protection by Fructus schisandrae against acetaminophen hepatotoxicity in mice. Liu GT;Wei HL
  11. Journal of Applied Toxicology v.20 Effects of phenylhydrazine or phlebomy on peripheral blood, bone marrow and erythropoietin in Wistar rats. Criswell KA;Sulkanen AP;Hochbaum AF;Bleavins MR
  12. Blood v.95 Identification and characterization of a bipotent(enfhroid and megakaryocytic) cell precursor from the spleen of phenylhydrazine-treated mice. Vannucchi AM;Paole沈i F;Linari 5;CellaiC;Caper리e a, Ferrini PR;Sanchez M;Migliaccio G;Migliaccio AR
  13. Journal of parasitology v.82 Experimental Babesia microti infection in golden hamsters: immunoglobulin Gresponse and recovery from severe hemolytic anemia. Hu R;Yeh MT;Hyland KE;Mather TN
  14. Hepatology v.31 Hemolytic anemia induced by ribavirintherapy in patients with chronic hepatitisC virus infection: role of membraneoxidative damage. De Franceschi L;Fattovich G;Turrini F ;Ayi K;Brugnara C;Manzato F;Noventa F;Stanzial AM;Solero P;Corrocher R
  15. Journal of Nutrition v.127 Invivo dopamine metabolismis is altered in iron-deficient anemic rats. Nelson C;Erikson K;Pinero BJ;Beard JL.
  16. American Journal of Pysiology v.255 Invivo transferrin-iron receptor relationships in erythron of rats. Intragumtornchai T;Huebers HA;Eng M; Finch CA..
  17. Free Radical Research. v.30 Iron release in erythrocytes from patients with beat-thslassemia. Ciccoli L;Signorini C;Scarano C;Rossi Iron ;Bambagioni ;Ferrali M;Compoi M