Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
권호 표지

Inhibitory effects of Injinseulki on Chemical-induced hepatic fibrosis in Rats

인진슬기의 간섬유화 억제 효과

  • Jang S.I. (Microbiology and Immunology, Wonkwang University, School of Medicine) ;
  • Kim H.J. (Microbiology and Immunology, Wonkwang University, School of Medicine) ;
  • Hwang K.M. (Microbiology and Immunology, Wonkwang University, School of Medicine) ;
  • Kwon T.O. (Medicinal Resources Center of Wonkwang University) ;
  • JeKal S.J. (Clinical Pathology, Wonkwang Health Science College) ;
  • Kim Y.C. (Medicinal Resources Center of Wonkwang University) ;
  • Pae H.O. (Medicinal Resources Center of Wonkwang University) ;
  • Choi B.M. (Medicinal Resources Center of Wonkwang University) ;
  • Shim J.S. (ImSil phytomedicinal Incorperation) ;
  • Kwak J.S. (MaSan College) ;
  • Chung H.T. (Medicinal Resources Center of Wonkwang University) ;
  • Yun Y.G. (Medicinal Resources Center of Wonkwang University)
  • 장선일 (원광대학교 의과대학 미생물 및 면역학교실) ;
  • 김형진 (원광대학교 의과대학 미생물 및 면역학교실) ;
  • 황기명 (원광대학교 의과대학 미생물 및 면역학교실) ;
  • 권태오 (원광대학교 의약자원연구센터) ;
  • 제갈승주 (원광보건대학 임상병리학과) ;
  • 김윤철 (원광대학교 의약자원연구센터) ;
  • 배현옥 (원광대학교 의약자원연구센터) ;
  • 최병민 (원광대학교 의약자원연구센터) ;
  • 심재석 (임실생약조합법인) ;
  • 곽준수 (마산대학교) ;
  • 정헌택 (원광대학교 의약자원연구센터) ;
  • 윤용갑 (원광대학교 의약자원연구센터)
  • Published : 2002.12.30
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Abstract

The inhibitory effects of Injinseulki including extracts of melanian snail plus phytomedicinal plants on $CCl_4$-induced fibrosis, $IFN-{\gamma}$ plus LPS-induced production of NO, PMA-stimulated production $O_2$, and tacrine-induced hepatic injury were investigated in rats, RAW 264.7 or HepG2 cells. The ethanol extracts of melanian snail significantly inhibited tarcrine-induced inury of HepG2 cells. Injinseulki inhibited the production of NO and $O_2$ in a dose-dependent manner in activated RAW 264.7 macrophages. Injinseulki significantly inhibited chemical-induced fibrosis in Rats. These results show that Injinseulki including extracts of melanian snail plus phytomedicinal plants may explain some known biological activities of Injinseulki including their anti-inflammatory and anti-fibrotic effect, and is of considerable benefit in the treatment for live diseases.

Keywords

References

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