• Title/Summary/Keyword: Injinseulki

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Inhibitory effects of Injinseulki on Chemical-induced hepatic fibrosis in Rats (인진슬기의 간섬유화 억제 효과)

  • Jang S.I.;Kim H.J.;Hwang K.M.;Kwon T.O.;JeKal S.J.;Kim Y.C.;Pae H.O.;Choi B.M.;Shim J.S.;Kwak J.S.;Chung H.T.;Yun Y.G.
    • Herbal Formula Science
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    • v.10 no.2
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    • pp.225-241
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    • 2002

  • The inhibitory effects of Injinseulki including extracts of melanian snail plus phytomedicinal plants on $CCl_4$-induced fibrosis, $IFN-{\gamma}$ plus LPS-induced production of NO, PMA-stimulated production $O_2$, and tacrine-induced hepatic injury were investigated in rats, RAW 264.7 or HepG2 cells. The ethanol extracts of melanian snail significantly inhibited tarcrine-induced inury of HepG2 cells. Injinseulki inhibited the production of NO and $O_2$ in a dose-dependent manner in activated RAW 264.7 macrophages. Injinseulki significantly inhibited chemical-induced fibrosis in Rats. These results show that Injinseulki including extracts of melanian snail plus phytomedicinal plants may explain some known biological activities of Injinseulki including their anti-inflammatory and anti-fibrotic effect, and is of considerable benefit in the treatment for live diseases.

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