Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Effect of Hyulbuchukeo-tang and its Component Groups on Alloxan Induced Hepatoxicity in Rats

혈부축어탕(血府逐瘀湯)과 그 구성약물군(構成藥物群)이 Alloxan 유도 당뇨(糖尿) 백서(白鼠)의 간독성에 미치는 영향

  • Park Sun-Dong (Department of Oriental Medical Prescription Dongguk University)
  • 박선동 (동국대학교 한의과대학 방제학교실)
  • Published : 2002.06.20
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Abstract

This study was performed to observe the effect of hyulbuchukeo-tang and its component groups on recovery of hepatoxicity in alloxan treated rats. The experimental group was divided into 3 groups: hyulbuchukeo-tang(HCT) and its components groups, sayeok-san(H-sa) and dohong-samul-tang (H-do). The results were obtained as follows: 1. The level of Glucose was considerably reduced by HCT, H-sa, H-do with high significancy. 2. In the change of GOT activity, HCT and H-do were decreased with high significancy, H-do was decreased with some significancy. 3. In the change of GPT activity, HCT was decreased with high significancy, H-sa and H-do were decreased with some significancy. 4. In the change of ${\gamma}-GPT$ activity, HCT was decreased with high significancy, H-do was decreased with some significancy. 5. In the change of ALP activity. only HCT was decreased with some significancy. 6. In the change of LDH activity, HCT was decreased with high significancy, H-sa and H-do were decreased with some significancy. 7. In the change of bilirubin contents. only HCT was decreased with some significancy. As result, hyulbuchukeo-tang(HCT) has significant effects on recovery of hepatoxicity, and its components groups. sayeok-san(H-sa) and dohong-samul-tang(H-do) have some effects. It suggests that sayeok-san(H-sa) and dohong-samul-tang(H-do) have more effects on recovery of hepatoxicity in case of the combination of the two (that is hyulbuchukeo-tang) than in case of the separation.

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References

  1. 現代東洋醫學 v.10 no.3 慢性肝炎の漢方治療槪論 原桃介
  2. 瘀血硏究(제2회瘀血總合科學硏究會講演記錄集) 瘀血と血液粘度 有地滋;谿忠人
  3. 岐醫大紀 v.6 熊崎平膝
  4. 臨床病理file 이귀령(外)
  5. 醫林改錯 王淸任
  6. 方劑學 上海中醫學院
  7. 漢方治療白話 v.4 矢數道明
  8. 日本東洋醫學雜誌 v.16 肝障害に對すゐ漢方治療 三谷和合
  9. 日本東洋醫學雜誌 v.22 慢性肝炎に對すゐ瘀血劑の效果 有地滋
  10. 원광대학교 석사학위논문 血府逐瘀湯이 Thioacetamide에 의한 白鼠肝損傷에 미치는 영향 金榮睦
  11. J. of Medical Technology v.22 Miwa, I.;Toyoda, Y.;Okuda, J.
  12. Am. J. Clin. Patrol. no.28 A colorimetic method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transminases Retman, S.;Frankel, S.
  13. Vnitr. Lek. v.15 no.4 Serum gamma glutamyl transpeptidase activity in diseases of the liver and gallbladder (except infection jaundice) Divon, D.M.
  14. Agressologie. v.14 no.5 Changs of enzyme activity in some organs following thymectomy Petkoba, J.;Popova, N.;Kemileva, Z.
  15. Jpn. J. Clin. Chem. v.27 no.8 Clinical Chemistry Mashige, F.;Tanaka, N.;Maki, A.;Kamei, S.;Yananaka, M.
  16. 漢方醫學用語大辭典 蔡仁植(外)
  17. 活血化瘀硏究 姜春華
  18. 傷科學 上海中醫學院
  19. 漢方臨床病理學 鄭遇悅(外)
  20. 福健中醫藥 v.16 no.110 從活血化瘀十方試探王淸任的臨床思惟 葉威禮
  21. 本草學 李尙仁
  22. 中藥大辭典 江蘇新醫學院
  23. 本草綱目 李時珍
  24. 中醫方劑現代硏究 謝鳴(外)
  25. Diabetes v.35 The glucokinase glucose sensor on Human pancreatic islet tissue Beyada, F.J.;Wilson, J.M.;Ghosh, A.K.;Finegold, D.;Matschimsky, F.M.
  26. Diabetes v.35 Identification of glucokinase as the alloxan-sentive glucose sensor of the pancreatic $\beta$-cell Meglasson, M.D.;Burch, P.T.;Bemer, P.K.;Najafh, H.;Marchisky, F.M.
  27. 증상별임상검사 醫學敎育硏究院(篇)
  28. HANDY 임상검사법 理工産業編輯部(編)
  29. Am. J. Clin. Patrol. no.28 A colorimetic method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases Retman, S.;Frankel, S.
  30. Nippon-Jinzo-Gakkaishi v.33 no.1 Effect of uremic middle molecules removed during hemifiltration on the enzyme activity in rat liver cystol Konobu, K.;Yamamoto, E.;Toyomoto, M.;Sawanishi, K.
  31. Sulfur Amino Acids: Biochemical and Clinical Aspects Liver glutathione as a reservoir of L-cystine Higashi, T.;Tateishi, N.;Sakamioto, Y.
  32. 생화학 Albert L. Lehninger