Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
권호 표지

CURRENT REVIEW OF MOLECULAR BIOLOGY IN DISTRACTION OSTEOGENESIS

신연 골형성술에 있어서의 분자생물학적 최신 지견

  • Jee, Yu-Jin (Division of Oral & Maxillofacial Surgery, Department of Dentistry, The Catholic University) ;
  • Song, Hyun-Chul (Division of Oral & Maxillofacial Surgery, Department of Dentistry, The Catholic University) ;
  • Kim, Yeo-Gab (Dept. of Oral and Maxillofacial surgery, college of Dentistry, Kyung Hee University) ;
  • Kim, Jin (Division of Oral & Maxillofacial Surgery, Department of Dentistry, The Catholic University) ;
  • Kim, Chang-Hyen (Division of Oral & Maxillofacial Surgery, Department of Dentistry, The Catholic University)
  • 지유진 (가톨릭대학교 치과학교실 구강악안면외과) ;
  • 송현철 (가톨릭대학교 치과학교실 구강악안면외과) ;
  • 김여갑 (경희대학교 치과대학 구강악안면외과학교실) ;
  • 김진 (가톨릭대학교 치과학교실 구강악안면외과) ;
  • 김창현 (가톨릭대학교 치과학교실 구강악안면외과)
  • Published : 2002.12.31
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Abstract

Distraction osteogenesis is a well-established clinical treatment for limb length discrepancy and skeletal deformities. Appropriate mechanical tension-stress is believed not to break the callus but rather to stimulate osteogenesis. In contrast to fracture healing, the mode of bone formation in distraction osteogenesis is primarily intramembranous ossification. Although the biomechanical, histological, and ultrastructural changes associated with distraction osteogenesis have been widely described, the basic biology of the process is still not well known. Moreover, the molecular mechanisms in distraction osteogenesis remain largely unclear. Recent studies have implicated the growth factor cascade is likely to play an important role in distraction. And current reserch suggested that mechanical tension-stress modulates cell shape and phenotype, and stimulates the expression of the mRNA for bone matrix proteins. This article presents the hypotheses and current research that have furthered knowledge of the molecular biology that govern distraction osteogenesis. The gene regulation of growth factors and extracellular matrix proteins during distraction osteogenesis are discussed in this article. It is believed that understanding the biomolecular mechanisms that mediate distraction osteogenesis may guide the development of targeted strategies designed to improve distraction osteogenesis and accelerate bone healing.

Keywords

References

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