Journal of the Korean Association of Oral and Maxillofacial Surgeons

  • 제28권4호
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  • Pages.290-301
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  • 2002
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  • 2234-7550(pISSN)
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  • 2234-5930(eISSN)
대한구강악안면외과학회 (The Korean Association of Oral and Maxillofacial Surgeons)
권호 표지

백서에서 흡수성막과 탈회동결건조골을 이용한 두개골결손부의 골재생

GUIDED BONE REGENERATION OF CALVARIAL BONE DEFECTS USING BIOABSORBABLE MEMBRANE AND DEMINERALIZED FREEZE DRIED BONE IN RATS

  • 김수민 (조선대학교 치과대학 구강악안면외과학교실, 조선대학교 치과대학 구강생물학연구소) ;
  • 여환호 (조선대학교 치과대학 구강악안면외과학교실, 조선대학교 치과대학 구강생물학연구소) ;
  • 김수관 (조선대학교 치과대학 구강악안면외과학교실, 조선대학교 치과대학 구강생물학연구소) ;
  • 임성철 (조선대학교 의과대학 병리학교실)
  • Kim, Soo-Min (Dept. of Oral & Maxillofacial Surgery, Oral Biology Research Institute, College of Dentistry, Chosun University) ;
  • Yeo, Hwan-Ho (Dept. of Oral & Maxillofacial Surgery, Oral Biology Research Institute, College of Dentistry, Chosun University) ;
  • Kim, Su-Gwan (Dept. of Oral & Maxillofacial Surgery, Oral Biology Research Institute, College of Dentistry, Chosun University) ;
  • Lim, Sung-Chul (Department of Pathology, Medical Research Institute, College of Medicine, Chosun University)
  • 발행 : 2002.08.31
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초록

The purpose of this study was to evaluate new bone formation and healing process in rat calvarial bone defects using $BioMesh^{(R)}$. membrane and DFDB. Forty eight rats divided equally into 4 groups of 1 control group and 3 experimental groups. Standardized transosseous circular calvarial defects (8 mm in diameter) were made midparietally. In the control group, the defect was only covered with the soft tissue flap. In the experimental group 1, it was filled with DFDB only, in the experimental group 2, it was covered $BioMesh^{(R)}$. membrane only, and in the experimental group 3, it was filled DFDB and covered with membrane. At the postoperative 1, 2, 4, 8 weeks, rats were sacrificed and histologic and histomorphometric analysis were performed. These results were as follows. In histomorphometric analysis, It showed the greatest amount of new bone formation through experimental in the experimental group 3 (P<0.001). The amount of new bone formation at the central portion of the defect was greater in the experimental group 3 than experimental group 2. $BioMesh^{(R)}$. membrane began to resorb at 1 week and resorbed almost completely at 8 weeks after operation. The collapse of membrane into the defect was observed through the experimental periods in the experimental group 2. In the area of collapsed membrane, new bone formation was restricted. These results suggest that maintenance of some space for new bone to grow is required in the use of $BioMesh^{(R)}$. membrane alone in the defect. It is also thought that use of the membrane may promote new bone growth in DFDB graft.

키워드

참고문헌

  1. Alberius P, Dahlin C, Linde A: Role of osteopromotion in experimental bone grafting to the skull: a study in adult rats using a membrane technique. J Oral Maxillofac Surg 1992;50:829-834 https://doi.org/10.1016/0278-2391(92)90274-4
  2. Linde A, Alberius P, Dahlin C, Bjurstam K, Sundin Y: Osteopromotion: a soft-tissue exclusion principle using a membrane for bone healing and bone neogenesis. J Periodontol 1993;64:1116-1128 https://doi.org/10.1902/jop.1993.64.11s.1116
  3. 민승기, 이동근, 엄인웅: 냉동건조탈회동종골과 Bioglass의 골형성에 관한 실험적 연구. 대한악안면성형재건외과학회지 1995;17:137-149
  4. 박문성, 류선열: 골결손부의 신생골 형성에 미치는 흡수성, 비흡수성 및 우골유도 수산화인회석의 영향. 대한구강악안면외과학회지 1996;22:561-574
  5. 정승룡, 류선열, 김선헌: 발치와의 신생골형성에 미치는 탈회동결 건조골과 흡수성 수산화인회석의 영향. 대한악안면성형재건외과학회지 1995;17:239-252
  6. 김영균: 치아회분말과 치과용 연석고의 혼합매식과 동결건조경막을 이용한 조직유도 재생술에 관한 실험적 연구. 대한구강악안면외과학회지 1996;22:297-306
  7. Kim SG, Chung CH, Kim YK, Park JC, Lim SC: Use of particulate dentin-plaster of Paris combination with/without platelet-rich plasma in the treatment of bone defects around implants. Int J Oral Maxillofac Implants 2002;17:86-94
  8. Kim SG, Kim HK, Lim SC: Combined implantation of particulate dentine, plaster of Paris, and a bone xenograft (Bio-Oss) for bone regeneration in rats. J Craniomaxillofac Surg 2001;29:282-288 https://doi.org/10.1054/jcms.2001.0236
  9. Kim SG, Kim HK, Lim SC: Combined implantation of particulate dentine, plaster of Paris, and a bone xenograft (Bio-Oss) for bone regeneration in rats. J Craniomaxillofac Surg 2001;29:282-288 https://doi.org/10.1054/jcms.2001.0236
  10. Kim SG, Chung CH, Kim YK: Grafting defects using a particulate dentin-plaster of Paris combination for implant placement: a case report. Hosp Dent Oral Maxillofac Surg 2001;13:127-130
  11. Schwartz Z, Mellonig JT, Carnes DL Jr, de la Fontaine J, Cochran DL, Dean DD, Boyan BD: Ability of commercial demineralized freezedried bone allograft to induce new bone formation. J Periodontol 1996;67:918-926 https://doi.org/10.1902/jop.1996.67.9.918
  12. Shigeyama Y, D’Errico JA, Stone R, Somerman MJ: Commerciallyprepared allograft material has biological activity in vitro. J Periodontol 1995;66:478-487 https://doi.org/10.1902/jop.1995.66.6.478
  13. Urist MR: Recent Advances in Physiology of Bone. J Bone Joint Surg 1963;45:1305-1313 https://doi.org/10.2106/00004623-196345060-00018
  14. Mulliken JB, Glowacki J, Kaban LB, Folkman J, Murray JE: Use of demineralized allogeneic bone implants for the correction of maxillocraniofacial deformities. Ann Surg 1981;194:366-372 https://doi.org/10.1097/00000658-198109000-00015
  15. Caffesse RG, Nasjleti CE, Morrison EC, Sanchez R: Guided tissue regeneration: comparison of bioabsorbable and non-bioabsorbable membranes. Histologic and histometric study in dogs. J Periodontol 1994;65:583-591 https://doi.org/10.1902/jop.1994.65.6.583
  16. Dahlin C, Linde A, Gottlow J, Nyman S: Healing of bone defects by guided tissue regeneration. Plast Reconstr Surg 1988;81:672-676 https://doi.org/10.1097/00006534-198805000-00004
  17. Dahlin C, Gottlow J, Linde A, Nyman S: Healing of maxillary and mandibular bone defects using a membrane technique. An experimental study in monkeys. Scand J Plast Reconstr Surg Hand Surg 1990;24:13-19 https://doi.org/10.3109/02844319009004514
  18. Dahlin C, Alberius P, Linde A: Osteopromotion for cranioplasty. An experimental study in rats using a membrane technique. J Neurosurg 1991;74:487-491 https://doi.org/10.3171/jns.1991.74.3.0487
  19. Bowen JA, Mellonig JT, Gray JL, Towle HT: Comparison of decalcified freeze-dried bone allograft and porous particulate hydroxyapatite in human periodontal osseous defects. J Periodontol 1989;60:647-654 https://doi.org/10.1902/jop.1989.60.12.647
  20. Schliephake H, Neukam FW, Hutmacher D, Becker J: Enhancement of bone ingrowth into a porous hydroxylapatite-matrix using a resorbable polylactic membrane: an experimental pilot study. J Oral Maxillofac Surg 1994;52:57-63 https://doi.org/10.1016/0278-2391(94)90016-7
  21. Burchardt H: The biology of bone graft repair. Clin Orthop 1983;174:28-42
  22. Mellonig JT, Bowers GM, Cotton WR: Comparison of bone graft materials. Part II. New bone formation with autografts and allografts: a histological evaluation. J Periodontol 1981;52:297-302 https://doi.org/10.1902/jop.1981.52.6.297
  23. Urist MR: A bone morphogenetic system in residues of bone matrix in the mouse. Clin Orthop 1973;91:210-220 https://doi.org/10.1097/00003086-197303000-00029
  24. Reynolds MA, Bowers GM: Fate of demineralized freeze-dried bone allografts in human intrabony defects. J Periodontol 1996;67:150-157 https://doi.org/10.1902/jop.1996.67.2.150
  25. Brugnami F, Then PR, Moroi H, Leone CW: Histologic evaluation of human extraction sockets treated with demineralized freeze-dried bone allograft (DFDBA) and cell occlusive membrane. J Periodontol 1996;67:821-825 https://doi.org/10.1902/jop.1996.67.8.821
  26. Quintero G, Mellonig JT, Gambill VM, Pelleu GB Jr: A six-month clinical evaluation of decalcified freeze-dried bone allografts in periodontal osseous defects. J Periodontol 1982;53:726-730 https://doi.org/10.1902/jop.1982.53.12.726
  27. Landsberg CJ, Grosskopf A, Weinreb M: Clinical and biologic observation of demineralized freeze-dried bone allografts in augmentation procedures around dental implants. Int J Maxillofac Implants 1994;9:586-592
  28. Becker W, Urist MR, Tucker LM, Becker BE, Ochsenbein C: Human demineralized freeze-dried bone: inadequate induced bone formation in athymic mice. A preliminary report. J Periodontol 1995;66:822-828 https://doi.org/10.1902/jop.1995.66.9.822
  29. Becker W, Becker BE, Caffesse R: A comparison of demineralized freeze-dried bone and autologous bone to induce bone formation in human extraction sockets. J Periodontol 1994;65:1128-1133 https://doi.org/10.1902/jop.1994.65.12.1128
  30. Nyman S, Lang NP, Buser D, Bragger U: Bone regeneration adjacent to titanium dental implants using guided tissue regeneration: a report of two cases. Int J Oral Maxillofac Implants 1990;5:9-14
  31. Karring T, Nyman S, Gottlow J, Laurell L: Development of the biological concept of guided tissue regeneration--animal and human studies. Periodontol 2000 1993;1:26-35 https://doi.org/10.1111/j.1600-0757.1993.tb00204.x
  32. Schmitz JP, Hollinger JO: The critical size defect as an experimental model for craniomandibulofacial nonunions. Clin Orthop 1986;205:299-308
  33. Schmitz JP, Schwartz Z, Hollinger JO, Boyan BD: Characterization of rat calvarial nonunion defects. Acta Anat 1990;138:185-192 https://doi.org/10.1159/000146937
  34. Sandberg E, Dahlin C, Linde A: Bone regeneration by the osteopromotion technique using bioabsorbable membranes: an experimental study in rats. J Oral Maxillofac Surg 1993;51:1106-1114 https://doi.org/10.1016/S0278-2391(10)80450-1
  35. 손재희, 김종렬: 다양한 차단막을 이용한 가토 골결손부의 골조직유도재생술에 관한 실험적 연구. 대한구강악안면외과학회지 1997;23:474-486
  36. Fleisher N, de Waal H, Bloom A: Regeneration of lost attachment apparatus in the dog using Vicryl absorbable mesh (Polyglactin 910). Int J Periodontics Restorative Dent 1988;8:44-55
  37. 장도근, 송재철, 이용규, 김진수: 가토 하악골 결손부의 골재생에 있어서 n-PTFE의 효과. 대한구강악안면외과학회지 1997;23:487-496
  38. Greenstein G, Caton JG: Biodegradable barriers and guided tissue regeneration. Periodontol 2000 1993;1:36-45 https://doi.org/10.1111/j.1600-0757.1993.tb00205.x
  39. Zaner DJ, Yukna RA, Malinin TI: Human freeze-dried dura mater allografts as a periodontal biological bandage. J Periodontol 1989;60:617-623 https://doi.org/10.1902/jop.1989.60.11.617
  40. Hollinger JO: Preliminary report on the osteogenic potential of a biodegradable copolymer of polyactide (PLA) and polyglycolide (PGA). J Biomed Mater Res 1983;17:71-82 https://doi.org/10.1002/jbm.820170107
  41. Visscher GE, Robison RL, Maulding HV, Fong JW, Pearson JE, Argentieri GJ: Biodegradation of and tissue reaction to poly(DL-lactide) microcapsules. J Biomed Mater Res 1986;20:667-676 https://doi.org/10.1002/jbm.820200510
  42. Vuddhakanok S, Solt CW, Mitchell JC, Foreman DW, Alger FA: Histologic evaluation of periodontal attachment apparatus following the insertion of a biodegradable copolymer barrier in humans. J Periodontol 1993;64:202-210 https://doi.org/10.1902/jop.1993.64.3.202
  43. Brunel G, Piantoni P, Elharar F, Benque E, Marin P, Zahedi S: Regeneration of rat calvarial defects using a bioabsorbable membrane technique: influence of collagen cross-linking. J Periodontol 1996;67:1342-1348 https://doi.org/10.1902/jop.1996.67.12.1342
  44. Hurzeler MB, Quinones CR, Caffesse RG, Schupbach P, Morrison EC: Guided periodontal tissue regeneration in interproximal intrabony defects following treatment with a synthetic bioabsorbable barrier. J Periodontol 1997;68:489-497 https://doi.org/10.1902/jop.1997.68.5.489
  45. Becker W, Becker BE, Prichard JF, Caffesse R, Rosenberg E, Gian-Grasso J: Root isolation for new attachment procedures. A surgical and suturing method: three case reports. J Periodontol 1987;58:819-826 https://doi.org/10.1902/jop.1987.58.12.819
  46. Miller N, Penaud J, Foliguet B, Membre H, Ambrosini P, Plombas M: Resorption rates of 2 commercially available bioresorbable membranes. A histomorphometric study in a rabbit model. J Clin Periodontol 1996;23:1051-1059 https://doi.org/10.1111/j.1600-051X.1996.tb01803.x
  47. Becker W, Schenk R, Higuchi K, Lekholm U, Becker BE: Variations in bone regeneration adjacent to implants augmented with barrier membranes alone or with demineralized freeze-dried bone or autologous grafts: a study in dogs. Int J Oral Maxillofac Implants 1995;10:143-154
  48. Anderegg CR, Martin SJ, Gray JL, Mellonig JT, Gher ME : Clinical evaluation of the use of decalcified freeze-dried bone allograft with guided tissue regeneration in the treatment of molar furcation invasions. J Periodontol 62:264-268, 1991