Journal of the Korean Association of Oral and Maxillofacial Surgeons

  • 제28권4호
  • /
  • Pages.280-285
  • /
  • 2002
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  • 2234-7550(pISSN)
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  • 2234-5930(eISSN)
대한구강악안면외과학회 (The Korean Association of Oral and Maxillofacial Surgeons)
권호 표지

키토산이 조골세포에 미치는 영향

EFFECTS OF CHITOSAN ON HUMAN OSTEOBLASTS

  • 김기홍 (한림대학교 의과대학 구강악안면외과학교실) ;
  • 박영주 (한림대학교 의과대학 구강악안면외과학교실) ;
  • 박준우 (한림대학교 의과대학 구강악안면외과학교실) ;
  • 이용찬 (한림대학교 의과대학 구강악안면외과학교실) ;
  • 조병욱 (한림대학교 의과대학 구강악안면외과학교실) ;
  • 안병근 (한림대학교 의과대학 구강악안면외과학교실)
  • Kim, Ki-Hong (Department of Oral & Maxillofacial Surgery, College of Medicine, Hallym University) ;
  • Park, Young-Ju (Department of Oral & Maxillofacial Surgery, College of Medicine, Hallym University) ;
  • Park, Jun-Woo (Department of Oral & Maxillofacial Surgery, College of Medicine, Hallym University) ;
  • Lee, Yong-Chan (Department of Oral & Maxillofacial Surgery, College of Medicine, Hallym University) ;
  • Cho, Byoung-Ouck (Department of Oral & Maxillofacial Surgery, College of Medicine, Hallym University) ;
  • Ahn, Byoung-Keun (Department of Oral & Maxillofacial Surgery, College of Medicine, Hallym University)
  • 발행 : 2002.08.31
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초록

As the result of the study concerning "bone inducibility of chitosan", 1. "BMP-2" was observed mainly through the test when the "osteoblast" is exposed to the "chitosan". The expression of BMP-2 was 542.63 times compared to control after 2 hours exposure and it was maintained 16.60 times till 24 hours. 2. The expression of BMP-4 was decreased compared to control during exposure. 3. The expression of BMP-7 revealed two peaks during exposure. 4. The expression of osteocalcin was increased in early phase, and then decreased. Although it is not clear whether the "chitosan" is clinically effective material as a "bone induction material", we could say that it has a function for bone induction. Further detailed study will be required.

키워드

참고문헌

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