Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Preparation and Evaluation of Titrated Extract of Centella Asiatica Niosome/W/O System Cream for Site Specific Targeting

니오좀을 이용한 병풀 추출물 외용제의 제조 및 평가

  • Kim, Dong-Woo (College of Pharmacy, Chungnam National University) ;
  • Cho, Mi-Hyun (College of Pharmacy, Chungnam National University) ;
  • Park, Sun-Young (College of Pharmacy, Chungnam National University) ;
  • Lee, Jong-Hwa (College of Pharmacy, Chungnam National University) ;
  • Lee, Gye-Won (Dep. of Pharmaceutical Engineering, Konyang University) ;
  • Park, Mork-Soon (Dongkook Pharmaceutical Research Institute) ;
  • Park, Jin-Kyu (Dongkook Pharmaceutical Research Institute) ;
  • Jee, Ung-Kil (College of Pharmacy, Chungnam National University)
  • Published : 2002.12.20
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Abstract

For preventing and curing the stretching mark, TECA Niosome/W/O system creams were formulated using Titrated Extract of Centella Asiatica (TECA) which is well known for its excellent wound healing effect. The lipid-water partition coefficients and the stabilities of TECA were evaluated and TECA Niosome/W/O system (TECA N/W/O) creams were prepared with different concentrations of cetyl alcohol and ceramide. TECA N/W/O cream was evaluated with respect to their rheological properties, permeation through excised skin of hairless mouse and in vitro and in vivo accumulation in the skin of hairless mouse. In addition, dermal thicknesses of hairless mouse skins were determined following the in vivo application of TECA N/W/O cream and control cream. TECA N/W/O creams showed pseudoplastic flow and hysteresis loop. The permeation of TECA from formulations through excised skin of hairless mouse did not observed. Amount of accumulated drug in the excised skin of hairless mouse was deσeased with an increase in the concentration of cetyl alcohol and showed no relationship with concentration of ceramide. Amount of accumulated drug in formulation A-3 was higher than in niosome suspension and other formulations. In in vivo experiment, amount of accumulated drug in formulation A-2 and A-3 was much higher than that of niosome suspension. Being treated with the N/W/O cream for 8 weeks, the dermal thickness of hairless mouse skin was increased 3.2 times than that of 16 weeks-control group.

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