Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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A Release Test for Gels Containing Ketoprofen

겔제제로부터 케토프로펜의 방출특성 시험법

  • Kim, Ho-Jeong (Department of Drug Evaluation, Korea Food and Drug Administration) ;
  • Yun, Mi-Ok (Department of Drug Evaluation, Korea Food and Drug Administration) ;
  • Lee, Su-Jung (Department of Drug Evaluation, Korea Food and Drug Administration) ;
  • Choi, Hyun-Chul (Department of Drug Evaluation, Korea Food and Drug Administration) ;
  • Kim, Ji-Young (Department of Drug Evaluation, Korea Food and Drug Administration) ;
  • Kim, In-Wha (Institute of Pharmaceutical Research, College of Pharmacy, Seoul National University) ;
  • Shim, Chang-Koo (Institute of Pharmaceutical Research, College of Pharmacy, Seoul National University) ;
  • Kang, Shin-Jung (Department of Drug Evaluation, Korea Food and Drug Administration)
  • 김호정 (식품의약품안전청 의약품평가부) ;
  • 윤미옥 (식품의약품안전청 의약품평가부) ;
  • 이수정 (식품의약품안전청 의약품평가부) ;
  • 최현철 (식품의약품안전청 의약품평가부) ;
  • 김지영 (식품의약품안전청 의약품평가부) ;
  • 김인화 (서울대학교 종합약학연구소) ;
  • 심창구 (서울대학교 종합약학연구소) ;
  • 강신정 (식품의약품안전청 의약품평가부)
  • Published : 2002.06.20
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Abstract

A method that describes the determination of the in vitro release of ketoprofen from gels was suggested. The experimental system of the method consists of a Franz diffusion cell, which contains a pH 7.4 phosphate buffer as a receptor medium, and a $70\;{\mu}m$ mesh woven nylon membrane as a diffusion barrier. Under the given condition of the system, the diffusion of ketoprofen across the membrane was rapid enough that the apparent release profile of ketoprofen obtained from the present method could represent the release of the drug from gel preparations. The release of ketoprofen in the present method was reproducible, and the rate increased in proportion to the concentration of ketoprofen in the gel. These suggest that the present method is applicable to the quality evaluation of gel preparations containing ketoprofen.

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References

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