Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Effect of Silk Fibroin Hydrolysate on Adipocyte Metabolism in db/db Mice

실크 피브로인 산 가수분해물이 db/db mice의 지방세포 대사에 미치는 영향

  • Hong, Seong-Eui (Department of Biotechnology, Graduate School, Handong University) ;
  • Park, Kum-Ju (Department of Biotechnology, Graduate School, Handong University) ;
  • Suh, Byung-Sun (School of Bioscience and Food Technology, Handong University) ;
  • Do, Myoung-Sool (School of Bioscience and Food Technology, Handong University) ;
  • Hyun, Chang-Kee (School of Bioscience and Food Technology, Handong University)
  • 홍성의 (한동대학교 대학원 생명공학과) ;
  • 박금주 (한동대학교 대학원 생명공학과) ;
  • 서병선 (한동대학교 생물식품공학부) ;
  • 도명술 (한동대학교 생물식품공학부) ;
  • 현창기 (한동대학교 생물식품공학부)
  • Published : 2002.12.30
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Abstract

Effect of the acid hydrolysate of silk fibroin on obesity was investigated in obese(057BL/KsJ-db/db) mice. After 8 weeks feeding of 1%(w/w) or 3%(w/w) fibroin hydrolysate, the extents of reduction in body weight were significantly higher than that of obese control. The weight reduction in female mice was higher than that in male mice. Plasma leptin in male mice increased up to 1.8-fold higher level than obese control by feeding hydrolysate. In case of female mice, however, it rather decreased with increased feeding concentration of hydrolysate. From the results of high glycine and serine contents of peptide fractions contained in fibroin hydrolysate, it was inferred that fibroin peptides might affect xylosyltransferase(XT) activity on chondroitin sulfate synthesis causing to change susceptibility of adipocytes to hormones such as insulin followed by the reduced leptin synthesis in female mice. The result of the higher lipolysis in hydrolysate-fed group than obese control indicated that the reduction in body weight was due to the increased lipolytic activities in male and female mice in common.

Keywords

References

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