Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Antigastritic and Anti-ulcerative Effect of P020701

생약복합제 P020701의 항위염 및 항궤양 효과

  • 현진이 (덕성여자대학교 약학대학) ;
  • 강민희 (덕성여자대학교 약학대학) ;
  • 김현표 (덕성여자대학교 약학대학) ;
  • 박지만 (덕성여자대학교 약학대학) ;
  • 이상윤 ((주)풀무원 테크) ;
  • 정춘식 (덕성여자대학교 약학대학)
  • Published : 2002.12.30
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Abstract

Present study was carried out for development of a new supplementary product with gastroprotective effect. Natural Products mentioned that have GI protective property in Dongeuibogam and reports were evaluated anti-bacterial activity against Helicobacter pylori, then five heres were selected. The material used for the test were water extract of Alpinia oxyphlla (AO), Astragalus membranaceus (AM), Cinnamomum loureirii(CL), Citrus aurantium(CA), Amomum villosum(AV). They were tested individually on HCI ethanol-induced gastric lesion in rats, AV CL, AO showed the most significant effectiveness, respectively. Then two mixture different in their content ratio (P020701-1,-2) and complex with P020701-1 (CP) were made, and tested on HCI·ethanol, indomethacin-induced gastric lesion, aspirin-ligature, Shay ulcer and gastric secretion. P020701-1, -2 and CP showed significant effect on HCI ethanol, indomethacin-induced gastric lesion, and Shay ulcer. It can be regarded that the antigasuitic and anti-ulcerative effects of P020701- 1, -2 and CP are originated from reduction of total acid output identified by gastric secretion test.

Keywords

References

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