생약학회지 (Korean Journal of Pharmacognosy)

한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

식물추출물의 Matrix Metalloproteinase-2에 대한 저해활성

Inhibitory Activity of Plant Extracts on Matrix Metalloproteinase-2

  • Lee, Sang-Myung (Korea Research Institute of Bioscience and Biotechnology) ;
  • Chun, Hyo-Kon (Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Ho-Jae (Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Choong-Hwan (Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Jin-Hee (Korea Research Institute of Bioscience and Biotechnology) ;
  • Kho, Yung-Hee (Korea Research Institute of Bioscience and Biotechnology)
  • 발행 : 2002.06.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

The inhibitory effects of methanol extracts of 165 medicinal herbs on matrix metalloproteinase-2 (MMP-2) activity were investigated. Amongst the herbal extracts, Youngia denticulate, Platycarya strobilacea, Sedum kamtschaticum, Euscaphis japonica, and Comus controversa showed a significant inhibitory effect with above 80% at $1\;{\mu}g/ml$. Above mentioned five kind extracts, which exclude polyphenols and/or tannin by techniques for their removal, showed a mild inhibitory effect on MMP-2 activity except for Y. denticulate at the same concentration.

키워드

참고문헌

  1. Terranova, V. R., Liotta, L. A., Russo, R. G., and Martin, G. R. (1982) Role of laminin in the attachment and metasis of murine tumor cells. Cancer Res. 42: 2265-2269
  2. Chambers, A. F., and Matrisian, L. M. (1997) Changing views of the role of matrix metalloproteinases in metastasis. J. Natl. Cancer. Inst. 89: 1260-1270 https://doi.org/10.1093/jnci/89.17.1260
  3. Johnson, L. L., Dyer, R., and Hupe, D. J. (1998) Matrix metalloproteianses. Curr. Opin. Chem. Biol. 2: 466 471 https://doi.org/10.1016/S1367-5931(98)80122-1
  4. Melchiori, A., Albini, A., Ray, J. M., and Stetler-Stevenson, W. G. (1992) Inhibition of tumor cell invasion by a highly conserved peptide sequence from the matrix metalloproteinase enzyme prosegment. Cancer Res., 52: 2353-2356
  5. Noriko E., Dominic, F., and Isaiah, J. R, (1991) Inhibition of murine melanoma experimental metastasis by recombinant desulfatohirudin, a highly specific thrombin inhibitor. Cancer Res. 51: 4549-4556
  6. Wall, M. E., Wani, M. C., Brown, D. M., Fullas, R., Oswald, J. B., Josephson, F. R, Thornton, N. M., Pezzuto, J. M.,Beecher, C. W. W., Farnsworth, N. R., Cordell, G. A., Kinghom, A. D., (1986) EBect of tannins on screening of plant extracts for enzyme inhibitory activity and techniques for their removal. Phytochemistry 25: 2817-2820 https://doi.org/10.1016/S0031-9422(00)83748-6
  7. Tanaka, T., Jiang, Z. H., and Kouno, I., (1998) Distribution of ellagic acid derivatives and a diarylheptanoid in wood of Ptatycarya strobilacea. Phytochemistry 47: 851-854 https://doi.org/10.1016/S0031-9422(97)00670-5
  8. Lee, D. H., Kang, S. J., Lee S. H., Ro, J. S., Lee, K. S., Kinghorn, A. D., Phenolic compounds from the lesves of Cornus controversa. (2000) Phytochemistry 53: 405-407 https://doi.org/10.1016/S0031-9422(99)00502-6
  9. Stevens, J. F., Henkt, H., Elizabeth, T. E., Annabe, B. (1996) Flavonoid variation Eurasian sedum and sempervivum, Phytochemistry 41: 503-512 https://doi.org/10.1016/0031-9422(95)00573-0
  10. Stevens, J. F., Henkt, H., Roeland, C. H. J. Van. H., Elizabeth, T. E.. Maya, M. V. X. Van Den E., Marjan, W., Jan, H. Z. (1995) Distribution of alkaloids and tannins in the Crassulaceae, Biochem. Systems and Ecol. 23: 157-165 https://doi.org/10.1016/0305-1978(95)00082-6