Antioxidant Compounds from Twig of Morus alba

  • Jin, Wen-Yi (College of Pharmacy, Chungnam National University) ;
  • Na, Min-Kyun (College of Pharmacy, Chungnam National University) ;
  • An, Ren-Bo (College of Pharmacy, Chungnam National University) ;
  • Lee, Hyun-Yong (College of Pharmacy, Chungnam National University) ;
  • Bae, Ki-Hwan (College of Pharmacy, Chungnam National University) ;
  • Kang, Sam-Sik (Natural Products Research Institute, Seoul National University)
  • Published : 2002.12.01

Abstract

The MeOH extract of the twig of Morus alba L. (Moraceae) inhibited strong lipid peroxidation activity. In order to find out active principle from the plant, acivity-guided fractionation was performed and five antioxidant compounds were isolated. Their chemical structures were identified as 6-geranylapigenin (1), 6-geranylnorartocarpetin (2), resveratrol (3), oxyresveratrol (4) and quercetin (5) by physicochemical and spectrometric methods. Compounds 1-5 significantly inhibited lipid peroxidation in rat brain homogenate $(IC_{50}\;values\;of\;3.37,\;3.74,\;0.23,\;0.29\;and\;0.06\; {\mu}M,\;respectively)$.

Keywords

References

  1. Deshpande, V. H., Parthasarathy, P. C., Venkataraman, K., Four analogs of artocarpin and cycloartocarpin from Morus alba. tetrahedron Lett. 14, 1715-1719 (1968)
  2. Deshpande, V. H., Wakharkar, P. V., Rao, A. V., Wood phenolics of Morus species: Part. Isolation of a new flavone, mulberranol and a novel phenol, alboctalol from Morus alba. Indian J. Chem., 14B, 647-650 (1976)
  3. Fuaki, T. and Nomura, T., Revised structures of Albanins D and E, geranylated flavones from Morus alba. HeterocycIes. 32, 499-510 (1991) https://doi.org/10.3987/COM-91-5661
  4. Hikino, H., Mozuno, T., Oshima, Y, Konno, C., Validity of the Oriental medicines. 80. Antidiabetes drugs. 4. Isolation and hypoglycemic activity of moran A, a flycoprotein of Morus alba root barks. Planta Med. 2, 159-160 (1985)
  5. Hirakura, K., Hano, Y., Fukai, T., Nomura, T., Uzawa, J., Strutures of three new natural Diels-Alder type adducts, Kuwanons P and X, and Mulberrofuran J, from the cultivated Mullberry tree (Morus lhou Koidz.). Chem.Phann. Bull. 33, 1088-1096 (1985) https://doi.org/10.1248/cpb.33.1088
  6. Kim, S. Y., Gao, J. J., Lee, W. C., Ryu, K. S., Lee, K. R., Kim, Y. C., Antioxidative falvonoids from the leaves of Morus alba.. Arch. Pharm. Res. 22, 81-85 (1999) https://doi.org/10.1007/BF02976442
  7. Lee, E. J., Chae, O. H., Lee, M. S., Lee, H. K., Huh, H., Purification of anti-allergic compound from Mori Cortex Radicis extract. Yakhak Hoechi. 42, 395-402 (1998)
  8. Luo, S., Nemec, J., Ning, B. M., Anti-HIV flavonoids from Morus alba. Yunnan Zhiwu Yanjiu. 17, 89-95 (1995)
  9. Na, M. K., An, R. B., Lee, S. M., Min, B. S., Kim, Y. H., Bae, K. H., and Kang, S. S., Antioxidant compounds from the stem bark of Sorbus commixta. Nat. Prod. Sci. 8, 26-29 (2002)
  10. Nomura T., Fukai T., Narita T., Hypotensive constituent, kuwanon H, a new flavone derivative from the root bark of the cultivated mulberry tree (Morus alba L.) Heterocycles. 14, 1943-1951 (1980) https://doi.org/10.3987/R-1980-12-1943
  11. Nomura, T., Progress in the Chemistry of Organic Natural Products, Vol.53, Springer-VeiIag, New York. 1988, pp. 87-201
  12. Nomura, T. Fukai, T., Constituents of the cultivated mulberry tree VII. Isolation of three new isoprenoid-flavanones, kuwanon D, E, and F from root bark of Morus alba L. Planta Med. 42, 79-88 (1981) https://doi.org/10.1055/s-2007-971550
  13. Nomura, T., Fukai, T., Uno, J., Arai, T., Mullberrofuran A, a new isoprenoid 2-arylbenzofuran from the root bark of the cultivated mulberry tree (Morus alba L.). Heterocycles. 9, 1593-1601 (1978) https://doi.org/10.3987/R-1978-11-1593
  14. Oshima Y., Konno C., Hikino H., Matsushita K., Validity of riental medicines. Part 26. Structure of moracenin A, a hypotensive principle of Morus Root Barks. Heterocycles. 14, 1287-1290 (1980) https://doi.org/10.3987/R-1980-09-1287
  15. Ryu, S. Y., Choi, S. U., Lee, C. O., Lee, S. H., Ahn, J. W., Zee, O. R, Antitumor activity of some phenolic components in plants. Arch. Pharm. Res. 17, 42-44 (1994) https://doi.org/10.1007/BF02978247
  16. Ko, S. K., Whang, W. K., Kim, I. H., Stilbene Compounds from cultivated korean Rhubarb Rhizomes. Yakhak Hoeji 42, 1-4 (1998)
  17. Takasuki, M., Nagao, S., Ueno, S., Massamune, T., Shirata, A., Takahashi, K., Studies on phytoalexins of the Moraceae. 2. Moracins C and D, new phytoalexins from diseased mulberry. Chem. Lett. 11, 1239-1240 (1978)
  18. Takasuki, M., Nagao, S., Massamune, T., Shirata, A., Takahashi, K., Studies on phytoalexins of the Moraceae. Part 4. Structrues of moracins E, F, G, and H, new phytoalexins from diseased mulberry. Tetrahedeon Lett. 48, 4675-4678 (1979)
  19. Takasuki, M., Ishigawa, S., Massamune, T., Studies on phytoalexins of the Moraceae. 11. Abafurans A and B, geranyl 2-phenylbenzofurans from mulberry. Chem. Lett. S, 1221-1222 (1982)
  20. Takasuki, M., Ishigawa, S., Nagao, S., Massamune, T., Studies on phytoalexins of the Momceae. 12. Abafurans C, a natural DieIs-Alder adduct of a dehydroprenyl-2-phenylbenzofurans with a chalcone from mulberry. Chem. Lett. 8, 1223-1224 (1982)