Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Cytotoxicity of Lignans from Lindera erytherocarpa Makino

  • Lee, Sang-Myung (Korea Research Institute of Bioscience and Biotechnology) ;
  • Baek, Seung-Hwa (Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Choong-Hwan (Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Hyang-Burm (Korea Research Institute of Bioscience and Biotechnology) ;
  • Kho, Yung-Hee (Korea Research Institute of Bioscience and Biotechnology)
  • Published : 2002.09.01
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Abstract

Three lignans were isolated from a methanol extract of Lindera erytherocarpa Makino (Lauraceae) are evaluated in vitro cytotoxicity using three cancer cell line assay. The compounds were identified as methyllinderone (1), linderone (2), and kanakugiol (3) by spectroscopic methods. Amongst the compounds, methyllinderone (1) showed significant cytotoxicity against mouse melanoma (B16-FlO), human acetabulum fibrosarcoma (HT1080), and choronic myelogenous leukemia (K562) cancer cell lines with $ED_{50}$ values of 2.2, 2.5, 8.3 ${\mu}g/ml$, respectively.

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References

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