Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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NFAT Transcription Factor Inhibitory Constituents from Cnidium officinale

  • Lee, Im-Seon (College of Pharmacy, Chungnam National University) ;
  • Huong, Dang Thi Lan (College of Pharmacy, Chungnam National University) ;
  • Lee, Mi-Sun (Bio-Med RRC, Division of Life Sciences, Pai Chai University) ;
  • Kim, Jung-Woo (Bio-Med RRC, Division of Life Sciences, Pai Chai University) ;
  • Na, Doe-Sun (University of Ulsan College of Medicine) ;
  • Kim, Young-Ho (College of Pharmacy, Chungnam National University)
  • Published : 2002.09.01
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Abstract

Four hundred varieties of plant extracts were screened for inhibitory activity against the NFAT transcription factor which plays an important role in inducing immune response. Among them, the MeOH extract of Cnidium officinale showed potent activity, and the activity-guided separation yielded butylidenephthalide, senkyunolide A and falcarindiol as the active constituents. The $IC_{50}$ value of butylidenephthalide was $1.3{\times}10^{-4}\;M$ and was similar to that of senkyunolide A $(2.1{\times}10^{-4}\;M)$. Interestingly, falcarindiol showed higher activity $(IC_{50},\;2.6{\times}10^{-5}\;M)$ than the two phthalides.

Keywords

References

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