Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis and Reactions of New Thienopyridines, Pyridothieniopyrimidines and Pyridothienotriazines

  • Bakhite, E.A. (Chemistry Department, Faculty of Science, Assiut University) ;
  • Abdel Rahman, A.E. (Chemistry Department, Faculty of Science, Assiut University) ;
  • Mohamed, O.S. (Chemistry Department, Faculty of Science, Assiut University) ;
  • Thabet, E.A. (Chemistry Department, Faculty of Science, Assiut University)
  • Published : 2002.12.20
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Abstract

4-Aryl-3-cyano-6-(2'-thienyl)-pyridine-2(1H)-thiones(1a-c) were reacted with phenacyl bromide, chloro-N-arylacetanmides or 2-chloroacetylaminopyridine to furnish 2-functionalized 3-amino-4-aryl-6-(2'-thienyl)-thieno[2,3-b]pyridines 4a-c and 5a-c or 5d respecitively. The compounds 5a-d underwent different sequence of reactions to produce a variety of thienylpyridothienopyrimidines and, thienylpyridothienotriazines. Some of the prepared compounds were tested in vitro for their antimicrobial activities.

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