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Furo[3,2-h]quinoline Derivatives as a Gastric H+/K+-ATPase Inhibitors


Abstract

Furo[3,2-h]quinoline derivatives were synthesized as a gastric $H^+$/$K^+$-ATPase inhibitors. The oxycyclization of 7 and 8-positions in quinoline potentiated the inhibitory activity, while no significant changes in biological activity were observed by the variation of substituents in furan ring. The several furo[3,2-h]quinoline derivatives were worthy of in vivo investigation for their anti-secretory and anti-ulcer activity.

Keywords

References

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Cited by

  1. ChemInform Abstract: Furo[3,2-h]quinoline Derivatives as Gastric H+/K+-ATPase Inhibitors. vol.33, pp.36, 2010, https://doi.org/10.1002/chin.200236147