Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
권호 표지

Effects of Alcohol Intake, Genotypes of Aldehyde Dehydrogenase 2 and N-Acetyltransferase 2 on the Development of Laryngeal Cancer in Koreans

한국인의 후두암 발생에서 음주, Aldehyde Dehydrogenase 2(ALDH2)와 N-Acetyltransferase 2(NAT2) 유전자 다형성의 역할

  • Kwon Soon-Uk (Department of Otolaryngology-Head and Neck Surgery, Eulji General Hospital, College of Medicine, Eulji University) ;
  • Shim Yoon-Sang (Department of Otolaryngology-Head and Neck Surgery, Korea Cancer Center Hospital) ;
  • Lee Yong-Sik (Department of Otolaryngology-Head and Neck Surgery, Korea Cancer Center Hospital) ;
  • Hong Seong-Chool (Department of Otolaryngology-Head and Neck Surgery, Korea Cancer Center Hospital) ;
  • Kim Kwang-Il (Department of Otolaryngology-Head and Neck Surgery, Korea Cancer Center Hospital) ;
  • Hong Young-Joon (Department of Clinical Pathology, Korea Cancer Center Hospital) ;
  • Hong Seok-Il (Department of Clinical Pathology, Korea Cancer Center Hospital) ;
  • Kim Hyun-Joo (Department of Clinical Pathology, Korea Cancer Center Hospital) ;
  • Kim Heon (Department of Medicine, Graduate School, Chungbuk National University) ;
  • Lee Guk-Haeng (Department of Otolaryngology-Head and Neck Surgery, Korea Cancer Center Hospital)
  • 권순욱 (을지의과대학 을지병원 이비인후-두경부외과학교실) ;
  • 심윤상 (원자력병원 이비인후-두경부외과) ;
  • 이용식 (원자력병원 이비인후-두경부외과) ;
  • 홍성출 (원자력병원 이비인후-두경부외과) ;
  • 김광일 (원자력병원 이비인후-두경부외과) ;
  • 홍영준 (원자력병원 임상병리과) ;
  • 홍석일 (원자력병원 임상병리과) ;
  • 김현주 (원자력병원 임상병리과) ;
  • 김헌 (충북대학교 의과대학 예방의학교실) ;
  • 이국행 (원자력병원 이비인후-두경부외과)
  • Published : 2001.11.01
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Abstract

Objectives: Alcohol intake has been reported to be a risk factor of laryngeal cancer. Since the aldehyde dehydrogenase 2 (ALDH2) genotype is a major determinant of personal alcohol drinking habit, there is a possibility that ALDH2 genotype would be a risk factor for laryngeal cancer. N-Acetyltransferase 2 (NAT2) is a detoxifying enzyme and its polymorphism has been reported to be related to the risk of many environmental cancers. However, studies on the associations between these two genotypes and laryngeal cancer risk are scarce. We have assessed the effects of alcohol intake and the genotype of ALDH2 and NAT2 on the risk of laryngeal cancer in Koreans. Materials and Methods: Eighty-four pathologically proven laryngeal cancer patients and 168 age matched controls were included as the study subjects. Information about alcohol intake and smoking habit was collected using a self administered questionnaire. ALDH2 and NAT2 genotypes were analyzed using PCR-RFLP methods. Results: Alcohol intake was significant as a risk factor for laryngeal cancer (OR : 2.58, 95% CI : 1.24, 5.36), especially for supraglottic laryngeal cancer (OR : 3.24, 95% CI : 1.02, 10.31). Personal drinking habit was closely related with personal smoking habit, which was a potent risk factor of laryngeal cancer. In a stratified analysis according to the level of cumulative smoking amount, drinking was significant neither in light smokers (equal or less than 30 pack-years) nor in heavy smoker (over 30 pack-years). The ALDH2 genotype was significantly associated with the risk of laryngeal cancer in a univariate analysis. The statistical significance, however, disappeared after adjusting alcohol intake using a multiple conditional logistic model. The NAT2 genotype was not significant as a risk factor for laryngeal cancer. Conclusion: Alcohol drinking and ALDH2 genotype would have indirect effects on laryngeal cancer by their correlations with cigarette smoking or with alcohol drinking. It is less likely that the NAT2 genotype would be a potent risk factor of laryngeal cancer.

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