Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
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Ocular Complications after Injection of Intra-arterial Carboplatin in Gliomas - Report of Three Cases -

신경교종에서 뇌동맥내 Carboplatin주입후 발생한 안구 합병증 - 3례보고 -

  • Kim, Joo-Han (Department of Neurosurgery, College of Medicine, Korea University) ;
  • Lee, Jang-Bo (Department of Neurosurgery, College of Medicine, Korea University) ;
  • Chung, Yong-Gu (Department of Neurosurgery, College of Medicine, Korea University) ;
  • Park, Jung-Yul (Department of Neurosurgery, College of Medicine, Korea University) ;
  • Lee, Hun-Kap (Department of Neurosurgery, College of Medicine, Korea University) ;
  • Suh, Jung-Keun (Department of Neurosurgery, College of Medicine, Korea University)
  • 김주한 (고려대학교 의과대학 신경외과학교실) ;
  • 이장보 (고려대학교 의과대학 신경외과학교실) ;
  • 정용구 (고려대학교 의과대학 신경외과학교실) ;
  • 박정율 (고려대학교 의과대학 신경외과학교실) ;
  • 이훈갑 (고려대학교 의과대학 신경외과학교실) ;
  • 서중근 (고려대학교 의과대학 신경외과학교실)
  • Received : 2000.05.12
  • Accepted : 2001.04.14
  • Published : 2001.05.28
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Abstract

Carboplatin intra-arterial chemotherapy(IAC) has an advantage of increased uptake during the first passage of the drugs through tumor capillaries. Although not common, this type of therapy is known to cause neurological complications, myelosuppression, and ototoxicity. However, the incidence of ocular toxicity is reported to be rare. Eleven of our patients with glioma(Grade II Astrocytoma : 3, Grade III Astrocytoma : 1, Grade IV Astrocytoma : 5, Gliofibroma : 1, Oligodendroglioma : 1) underwent IAC regimen with carboplatin($300mg/m^2$) which were administrated after blood-brain barrier disruption. Of there, 3 patients had ocular complications after supra-ophthalmic IAC injection of carboplatin but fully recovered following steroid therapy. Although our results from IAC seem to be favorable for these patients, we suggest that its complications, such as ocular toxicity, need to be carefully considered prior to treatment.

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