개 피부병 유래의 Microsporum canis의 항진균제 감수성

Antifungal Susceptibility of Microsporum canis isolated from canine dermatophytosis

개 피부병 유래 Microsporum canis 57주와 표준균주 1주 등 58주를 broth microdilution test로 계통이 다른 7가지 항진균제에 대한 감수성을 조사하고 고찰하였다. M canis의 항진균주에 대한 MIC(기하평균) 측정에서 terbinafine은 $MIC{\leq}0.004{\sim}0.031(0.007){\mu}g/ml$, itraconazole은 $MIC{\leq}0.004{\sim}0.125(0.029){\mu}g/ml$, ketoconazole은 MIC $0.015{\sim}0.5(0.097){\mu}g/ml$, tolnaftage은 MIC $0.031{\sim}1(0.155){\mu}g/ml$순으로 감수성이 높았고, griseofulvine은 MIC $0.063{\sim}2(0.285){\mu}g/ml$, amphotericin B는 MIC $0.125{\sim}2(0.540){\mu}g/ml$, flucytosine(5-Fe)은 MIC $4{\sim}64(26.430){\mu}g/ml$으로 감수성이 낮았다.

The present study was conducted to examine the drug susceptibility of 57 strains of Microsporum canis isolated from dogs with dermatitis in Taegu, 1999. Antifungal susceptibility test was performed by the microdilution method, using 7 antifungal drugs as follows: itraconazole(I), terbinafine(T), ketoconazole(K), griseofulvin(G), amphotericin B(A), flucytosine(5-Fc)(F), tolnaftate(To). All tester strains of M canis were highly susceptible to T, I, K and To(geometric mean $MICs{\leq}0.007{\sim}0.155{\mu}g/ml$), while those were lowly susceptible to G, A and F(geometric mean MICs $0.285{\sim}26.430{\mu}g/ml$).