Journal of Korean Society of Occupational and Environmental Hygiene (한국산업보건학회지)

Korean Industrial Hygiene Association (한국산업보건학회)
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Relationship between Chromium Concentration in Male Rats Fluids and Erythrocytes after Inhalation Exposure of Soluble Hexavalent Chromium Compound

수용성 6가크롬을 흡입 노출 시킨 랫드의 체액과 적혈구중 크롬간의 관련성 연구

  • Kim, Kwang-Jong (Dept. of Preventive Medicine and Institute for Occupational and Environmetal Heath, College of Medicine, Korea University) ;
  • Kim, Hyun-Young (Industrial Chemicals Research Center, Industrial Sofety and Health Research Institute, KOSHA) ;
  • Yoon, Soo-Jong (Dept. of Preventive Medicine and Institute for Occupational and Environmetal Heath, College of Medicine, Korea University) ;
  • Lee, Eun-Il (Dept. of Preventive Medicine and Institute for Occupational and Environmetal Heath, College of Medicine, Korea University)
  • 김광종 (고려대학교 의과대학 예방의학교실 및 환경의학연구소) ;
  • 김현영 (한국산업안전공단 선업안전보건연구원 산업화학물질센터) ;
  • 윤수종 (고려대학교 의과대학 예방의학교실 및 환경의학연구소) ;
  • 이은일 (고려대학교 의과대학 예방의학교실 및 환경의학연구소)
  • Received : 2001.04.07
  • Accepted : 2001.04.26
  • Published : 2001.05.30
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Abstract

The goal of this study was to evaluate the relationship between ambient hexavalent chromium concentration and the concentration of the chromium in whole blood, plasma, erythrocytes, and its urinary excretion of male rats after inhalation exposure of sodium chromate during 1, 2, and 3 weeks. 1. Differences of mean chromium concentration in urine, whole blood, erythrocytes, and plasma of male rats exposed to sodium chromate by exposure level were statistically significance, respectively. 2. At low and high exposure groups, differences of mean chromium concentration in urine, whole blood, erythrocytes, and plasma of male rats by duration of inhalation exposure were statistically significance, respectively. 3. Ratio of whole blood chromium to plasma chromium increased with the increased duration of inhalation exposure of sodium chromate. 4. Ambient hexavalent chromium was positively and strongly correlated with in erythrocyte chromium, and also erythrocyte chromium was strongly correlated with in whole blood chromium. In conclusion, this study showed that chromium in erythrocyte increased with the increased exposure level and exposure duration, therefore this study suggests that chromium in erythrocytes is a good biological exposure index of the internal dose from exposure to soluble hexavalent chromium compound.

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