The Korean Journal of Nuclear Medicine (대한핵의학회지)
- Volume 35 Issue 4
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- Pages.258-267
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- 2001
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- 1225-6714(pISSN)
Effect of MK-801 on Methamphetamine-Induced Dopaminergic Neurotoxicity: Long-Term Attenuation of Methamphetamine-Induced Dopamine Release
MK-801이 메트암페타민에 의한 도파민 신경독성에 미치는 효과: 메트암페타민에 의한 도파민 유리의 장기간 억제
- Kim, Sang-Eun (Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
- Kim, Yu-Ri (Center for Clinical Research, Samsung Biomedical Research Institute) ;
- Hwang, Se-Hwan (Center for Clinical Research, Samsung Biomedical Research Institute)
- Published : 2001.08.30
Abstract
Purpose/Methods: Repeated administration of methamphetamine (METH) produces high extracellular levels of dopamine (DA) and subsequent striatal DA terminal damage. The effect of MK-801, a noncompetitive N-methyl-D-aspartate receptor antagonist, on METH-induced changes in DA transporter (DAT) and DA release evoked by an acute METH challenge was evaluated in rodent striatum uslng