YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Protective Effect of an Aged Garlic-bamboo Salt Mixture on the Rat with the Alcohol-salicylate Induced Gastropathy

마늘-죽염 제제가 위장 장애 유발 흰쥐의 항산화 효소활성에 미치는 영향

  • Huh, Keun (College of Pharmacy, Yeungnam University) ;
  • Kim, Young-Hee (Insan Institute of Biotechnology, Insanga Inc.) ;
  • Jin, Da-Qing (College of Pharmacy, Yeungnam University)
  • 허근 (영남대학교 약학대학 약리학연구실) ;
  • 김영희 ((주)인산가 부설 인산 생명 과학 연구소) ;
  • 김대경 (영남대학교 약학대학 약리학연구실)
  • Published : 2001.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

Garlic has been known to be effective against the gastrointestinal diseases which can be induced by production of oxygen-derived free radical. It has been shown that bamboo salt is effective on the treatment and prevention of various gastrointestinal disorders. Bamboo salt is a processed salt invented by a Korean, ll-Hoon Kim. It has been reported that garlic and bamboo-salt are useful to the treatment of gastric disorders in Korea. To clarify the protective mechanism of the garlic-bamboo salt mixture, the gas-tropathy was induced in rats with alcohol-salicylate and the activities of the free radical scavenging enzymes were examined. In this study, we found that the garlic-bamboo salt mixture reduced the severity of hemorrhagic lesion in gastric mucosa in the rats. In addition, the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) were significnatly increased and the total content of GSH was recovered. From those results, we concluded that the protective effect of the garlic-bamboo salt mixture on gastropathy in rats is its ability to recover the level of GSH and to increase the activities of the free radical scavenging enzymes (SOD, GPx, GR).

Keywords

References

  1. J. Gastroenterol. Hepatol. v.13 no.10 Role of endogenous nitric oxide in ischaemia-reperfusion injury of rat gastric mucosa Iwata, F.;Joh, T.;Yokoyama, Y.;Itoh, M.
  2. Dig. Dis. Sci. v.43 no.5 Role of nitric oxide in oxidative damage in isolated rabbit gastric cells exposed to hypoxia-reoxygenation Kim, H.;Kim, K. H.
  3. Eur. J. Cancer Prev. v.7 no.6 Inducible nitric oxide synthase, anti-oxidant enzymes and Helicobactor pylori infection in gastritis and gastric precancerous lesions in humans Pignatellin, B.;Bancel, B.;Esteve, J.;Malvaveille, C.;Calmels, S.;Correa, P.;Patricot, L. M.;Laval, M.;Lyandrat, N.;Ohshima, H.
  4. Aliment Pharmacol. ther. v.13 no.SUP.1 The role of inflammation in the pathogenesis of gastric cancer Lee, K. H.
  5. J. Biol. Chem. v.273 no.36 Oxidative stress activates the human histidine decarboxylase promoter in AGS gastric cancer cells Hocker, M.;Rosenberg, I.;Xavier, R.;Henihan, R. T.;Wiedenmann, B.;Rosewicz, S.;Podolsky, D. K.;Wang, T. C.
  6. FEBS Lett. v.382 no.1-2 Antioxidant properties of Omeprazol Lapnna, D.;Giois, S.;Ciofani, G.;Festi, D.;Cuccurullo, F.
  7. Am. J. Surg. v.170 no.6 Reflux esophagitis in humans is mediated by oxygen derived free radicals Wetscher, G. J.;Hinder, R. A.;Bagchi, D.;Hinder, P. R.;Bagchi, M.;Perdikis, G.;Mc Ginn, T.
  8. Crit. Rev. Food. Sci. Nutr. v.35 no.1-2 The role of antioxidants in gastric carcinogenesis Correa, P.
  9. J. Appl. Toxicol. v.181 Stress, diet and alcohol-induced oxidative gastrointestinal mucosal injury in rats and protection by bismuth subsalicylate Bagchi, D.;Carryl, O. R.;Tran, M. X.;Krohn, R. L.;Bagchi, D. J.;Garg, A.;Bagchi, M.;Mitra, S.;Stohs, S.J.
  10. Biochem. J. v.134 The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen Boveris, A.;Chance, B.
  11. Eur. J. Biochem. v.111 The metabolic fate of mitochondrial hydrogen peroxide Nohl, H.;Jordan, W.
  12. Lab. Invest. v.47 Biology of disease. Free radicals and tissue injury Freema, B.;Crapo, J. D.
  13. Biochem. Pharmacol. v.31 Activation of pharmacologic agents to radical intermediates: Implications for the role of free radicals in drug action and toxicity Trush, A. M.;Mimnaugh, E. G.;Gram, T. E.
  14. Biochem. Biophys. Res. Commun v.36 The production of superoxide anion radicals in the reaction of reduced flavins and flavoproteins with molecular oxygen Messey, V.;Strickland, S.;Mayhew, S. G.;Howell, L. G.;Howell, L. G.;Engel, P. C.
  15. Biochim. J. v.131 Milk xanthine oxidase type D(dehydrogenase) and type O(oxidase): Purification, interconversion and some properties Battelli, M. G.;Lorenzoni, E.;Stripe, F.
  16. The Physiologist v.26 Role of oxygen radicals in the pathogenesis of intestinal ischemia Granger, D. N.;Parks, D. A.
  17. New Eng J. Med. v.320 Beyond cholesterol modifications of low-density lipoprotein that increase its atherogenicity Steinberg, D.;Parthasarthy, S.;Carew, T. E.;Khoo, J. C.;Witzum J. L.
  18. Biochem. Med. v.21 Lipid peroxide level in plasma of diabetic patients Sato, Y.;Hotta, N.;Sakamodo, N.;Masuoka, S.;Ohishi, N.;Yaki, K.
  19. Biochem. J. v.245 Glucosa autoxidation and protein modification;The potential role of "autoxidative glycosylation" in diabetes Wolf, S. P.;Dean, R. T.
  20. Free radical in Biology Involvement of radical reactions in aging and carcinogenesis in medical chemistry Pryor, W. A.
  21. Free Rad. Biol. med. v.8 Heightened free radical activeity in pancreatitis Guyam, P. M.;Uden, S.;Braganza, J. M.
  22. Free. Radic. Biol. Med. v.26 no.5 Helicobactor pylori-associated gastric pro-and antioxidant formation in Mongolian gerbils Suzuki, H.;mori, M.;Seto, K.;Kai, A.;Kawakuchi, C.;Suzuki, M.;Suematzu, M.;Yoneda, T.;Miura, S.;Ishii, H.
  23. Natr, Cancer v.34 no.1 Low dose of diallyldisulfide, a compound derived from garlic, increase tissue active reductase and glutathione transferase in the gastrointestinal tract of the rat Munday, R.;Munday, C. M.
  24. Toxicol. Appl. Pharmacol. v.154 no.1 Modulation of phase Ⅱ enzymes by organosulfur compounds from allium vegetable Guyonnet, D.;Siess, M. H.;Le Bon, A. M.;Suschetet M.
  25. Biochem. Biophys. Acta. v.1379 no.2 The mode of action of allicin;Trapping of radicals and interaction with thiol containing proteins Ravinkov, A.;Miron, T.;Konstantionvski, L.;Xilchek, M.;Mirelman, D.;Weiner, L.
  26. Planta Med. v.60 no.5 Antioxidant and radical scavenging effects of aged garlic ext. and its constituents Imai, J.;Ide, N.;Naga, S.;Moriguchi, T.;Matsuura, H.;Itakura, Y.
  27. Vet. Hum. Toxicol. v.41 no.5 Antioxidant role of oils isolated garlic (Allium sativum Linn) and onion (Allium cepa Linn) on nicotine-induced lipid peroxidation Helen, A.;Rajasree, C. R.;Krishnakumar, K.;Augusti, K. T.;Vauayammal, P. L.
  28. Phytomedicine v.6 no.2 Aged garlic extract attenuates intracellular oxidative stress Ide, N.;Lau, B. H.
  29. Indian J. Exp. Biol. v.31 no.6 Antidiabetic effects of s-allyl cysteine sulfoxide isolated from garlic Allium sativum Linn Sbeela, C. G.;Augusti, K. T.
  30. Planta Med. v.61 no.4 Antidiabetic effects of anion and garlic sulfoxide amino acids in rats Sbeela, C. G.;Kumud, K.;Augusti, K. T.
  31. Biochem. Biophys. Res. Commun v.194 no.2 Allyl compounds selectively killed human immunodeficency virus(Type-1)-infected cell ShoJi, S.;Furuishi, K.;Yanase, R.;Miyazaka, T.;Kino, M.
  32. Nippon Yakurigaku Zasshi v.110 no.SUP.1 Garlic compounds protect vascular endothelial cells from oxidant injury Yamasaki, T.;Lau, B. H.
  33. Biochim. Biophys. Acta. v.1315 no.1 Diallylsulfide inhibits the proliferation of human tumor cells in culture Sundaram, S. G.;Milner, J. A.
  34. Cancer Lett. v.118 no.1 Mechanism of differential efficacy of garlic organo sulfides in preventing benzo(a)pyrene-induced cancer in mice Srivastava, S. K.;Hu, X.;Xia, H.;Zaren, H. A.;Chatterjee, M. L.;Agarwal, R.;Singh, S. V.
  35. Cancer Lett. v.66 no.3 Anticarcinogenic action of diallyl sulfide in hamster buccal pouch and forestomach Nagabhushan, M.;Line, D.;Polverini, P. J.;Solt, D. B.
  36. Arch. Biochem. Biophys. v.336 no.3 Glutathione S-transferase of female A/J mouse liver and forestomach and their differential induction by anticarcinogenic organosulfides from garlic Hux, Benson P. J.;Srivastava, S. k.;Mack, L. M.;Xia, H.;Gupta, V.;Zaren, H. A.;Singh, S. V.
  37. Carcinogenesis v.17 no.4 Diallyl disulfide induces apotosis of human colon tumor cells Sundaram, S. G.;Milner, J. A.
  38. Free Radic. Biol. Med. v.23 no.2 S-allyl cysteine inhibits activation of nuclear factor kappa B in human T cells Geng, Z.;Rong, Y.;Lau, B. H.
  39. Am. J. Chim. Med. v.27 no.1 Effect of garlic active principle, diallyl disulfde on cell viability, lipid peroxidation, glutathione concentration and its related enzyme activities in primary rat hepatocytes Sheen, L. Y.;Sheu, S. F.;Tsai, S. J.;Meng, R. H.;Lii, C. K.
  40. Experientia v.52 no.2 Antiperoxide effect of S-allyl cysteine sulfoxide, and insulin secretagogue in diabetic rats Augusti, K. T.;Sheela, C. G.
  41. Nippon Yakurigaku Zasshi v.110 no.SUP.1 Garlic compounds protect vascular endothelial cells from oxidant injury Yamasaki, T.;Lau, B. H.
  42. Atherosclerosis v.143 no.2 Daily supplementation with aged garlic extract, but not raw garlic protects low density lipoprotein against in vitro oxidation Munday, J. S.;James, K. A.;Fray, L. M.;Kirkwood, S. W.;Thompson K. G.
  43. Boll. Chim. Farm. v.132 no.2 The radical scavenging ability of garlic examined in various models Rietz, B.;Belagyi, J.;Torok, B.;Jacob, R.
  44. J. Toxicol. Environ. Health v.44 no.2 Differential effects of dietary diallyl sulfide and diallyl disulfide on rat intestinal hepatic drug-metabolizing enzymes Haber, D.;Siess, M. H.;Canivenc;Lavier, M. C.;LeBon, A. M.;Suschetet, M.
  45. Carcinogenesis v.9 no.1 Effects of organo sulfur compounds from garlic and onions on benzo [α] pyrene-induced neoplasia and glutathione-S-transferase(GST) activity in the mouse Sparmins, V. L.;Barany, G.;Wattenberg, L. W.
  46. Diallyl sulfide: Res. Commun. Mol. Pathol. Pharmacol. v.110 no.2 Mechanisms of the preventive properties of some garlic compounds in the carbon tetrachloride-promoted oxidative stress Fenelli, S. L.;Castro, G. D.;Toranzo, E. G.;Castro, J. A.
  47. 인산동천 신약 김일훈
  48. 인산동천(전) 신약본초 김일훈
  49. 인산동천(후) 신약본초 김일훈
  50. 응용약물학회지 v.7 죽염의 약리작용 평가 양지선;김옥희;정수영;유태무;노용남;이숙영;정면우;양미령;최현진;류항묵
  51. J. Fd. Hyg. v.13 no.3 죽염의 특성분석과 항위궤양효과 김승희;강석연;정기경;김태규;한형미;류항묵;문애리
  52. 대한 구강 보건 학회지 v.15 no.2 죽염과 식염의 구강내 세균증식 억제효과에 관한 비교연구 손우성;유윤정;김종렬
  53. 대한 구강 보건 학회지 v.18 no.1 수종한약제 및 죽염 함유 치약이 치태 및 치은염에 미치는 영향에 관한 임상적 연구 박경일;최유진
  54. 대한 구강 보건 학회지 v.18 no.2 Monofluorophosphate와 죽염과 alantoin chlorohydroxy aluminum 및 dl-α-tocopheral acetate를 배합한 특수 세치제의 치아우식 예방효과와 치은염 치유효과에 관한 실용실험적 연구 마득상;진보형;박덕영;김종배;백대일;문혁수
  55. 대한 구강 보건 학회지 v.19 no.2 죽염과 염화 세틸피리디늄배합 양치액의 치은염 억제에 미치는 영향에 관한 임상실험 연구 강명신;김형규;권호근;김종렬
  56. 대한 구강 보건 학회지 v.17 no.1 Cetylpyridinium chloride 및 죽염배합 양치용액의 구강다형 연쇄상 구균수 및 치면세균막 형성에 미치는 영향에 관한 실용 실험적 연구 김종배;백대일;문혁수;진보형;박덕영
  57. Clinical and basic experimental studies on Korean Insan Bamboo salt Wang Qi;Li Xiu Min;Gao Qin Ying;Wei Ya Jun;Luo Bin;Xu Wen Feng;Luo shang Wu;Chen He Liang
  58. Clinical and basic experimental studies on treating patients with gastric diseases with Korean Insan Bamboo salt(JukYom) Wang Qi;Li Xiu Min;Gao Qin Ying;Wei Ya Jun;Luo Bin;Xu Wen Feng;Luo shang Wu;Chen He Liang
  59. 韓國仁山竹物理學特性硏究報告論文集 v.3 金明寬
  60. J. Biol. Chem. v.244 The regulation of rat liver xanthine oxidase: Conversion in vitro of the enzyme activity from dehydrogenase (type D) to oxidase (type O) Sttirpe, F.;Della, C. E.
  61. Arch. Biochem. Biophys. v.255 Negative and positive assays of superoxide dismutase based on hematoxylin autoxidation Martin J. P.;Dailey, M.;Sugarman, E.
  62. J. Lab. Clin. Med. v.70 Studies on the quantitative and qualitative characterization of erythrocytes glutathione peroxidase Paglia, E. D.;Valentine W. N.
  63. J. Biol. Chem. v.237 Hepatic glutathione reductase: Purification and general kinetic properties Meiz, C. E.;Langdon, R. G.
  64. Anal. Biochem. v.106 Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine Griffith, O. W.
  65. J. Biol. Chem. v.193 Protein measurement with folin phenol reagent Lowry, O. H.;Rosebrough, N. J.;Rarr, A. L.;Randall, R. J.
  66. Drugs. v.3 Medical management of peptic ulcers with reference to antiulcer agents in other gastrointestinal disease Piper, D. W.;Heap, T. R.
  67. N. Eng. J. Med. v.311 Cimetidine, cigarette smoking and recurrence of duodenal ulcer Somtag, S.;Graham, D. Y.;Belsito, A.;Weiss, J.
  68. N. Eng. J. Med. v.328 Effect of ranitidine and amoxacillin plus metronidazole of the eradication of H.pylori and the recurrence of duodenal ulcer Hentschel, E.
  69. Bochus Gastroenterology Medical management of uncomplicated peptic ulcer disease Thomxon, A. B. lR.;Mayai, S.;Berk J. E.(ed.)
  70. 이우주의 약리학 강의 김경환
  71. 경상대학교 의과대학 Helicobacter pylori 연구센터 논문집 v.21 Helicobacter pylori 감염의 세균학적 특성 이광호
  72. 경상대학교 의과대학 Helicobacter pylori 연구센터 논문집 v.40 H. pylori에 의한 호중구 및 위점막 세포로부터 유도되는 LTB4의 생성에 미치는 Rebamipide의 영향 이정진;한복기;노재열;이광호;윤희상;정말남;정명희
  73. Communicable disease monthly report v.8 no.2 Helicobacrer pylori 감염증 경상대학교 의과대학 Helicobacter pylori 연구센터
  74. 제 65차 춘계학술대회 특강Ⅲ Helicobacter pylori에 의한 위암 원인론 이광호
  75. Cancer pharmacology Final report for JUKYOM;TOXICOLOGY AND ANTI-TUMOR ACTIVITY Beverly A. Teicher