Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Virus-cell Fusion Inhibitory Activity for the Polysaccharides from Various Korean Edible Clams

  • Woo, Eun-Rhan (College of Pharmacy, Chosun University) ;
  • Kim, Wan-Seok (Natural Products Research Institute, Seoul National University) ;
  • Kim, Yeong-Shik (Natural Products Research Institute, Seoul National University)
  • Published : 2001.12.01
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Abstract

In order to find potent virus-cell fusion inhibitory components from Korean edible clams, thirteen prepared polysaccharides were introduced to syncytia formation inhibition assay, which is based on the interaction between the HIV-1 envelope protein gp 120/41 and the cellular membutane protein CD4 of T lymphocytes. Among them, Meretrix petechialis showed a potent viruscell fusion inhibitory activity. Fusion index (F1) and percent (%) fusion inhibition of the polysaccharide of this clam were $0.21{\pm}0.02$, and $67.52{\pm}4.09$ at 100781m1, respectively. It exhibited almost equivalent virus-cell fusion inhibitory activity to that of dextran sulfate which was used as a standard control.

Keywords

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